Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

317 questions · 341 findings · 38 reviews · Vascular

No studies found 55 · 16.1%GRADE not reported 32 · 9.4%Very low 58 · 17%Low 117 · 34.3%Moderate 57 · 16.7%High 22 · 6.5%

Intramuscular injection of bone marrow mononuclear cells (BMMNC) vs control

Complications and side effects · people with CLI who were not suitable for revascularisation and showed no improvement in response to the best standard therapy

It is very uncertain whether intramuscular injection of bone marrow mononuclear cells (BMMNC) changes side effects and complications ( compared with control (very low certainty).

1 finding from 1 review

Intervention not reported

Post‐thrombotic syndrome (intermediate, 6 months to under 5 years after treatment) · patients diagnosed with acute DVT

The intervention probably leads to lower post‐thrombotic syndrome (intermediate, 6 months to under 5 years… (moderate certainty).

1 finding from 1 review

Low molecular weight heparin vs UFH

Incidence of recurrent VTE1 after initial treatment (up to 15 days) · patients with venous thromboembolism.

LMWH probably leads to lower incidence of recurrent VTE1 after initial treatment (up to 15 days) compared with UFH (moderate certainty).

1 finding from 1 review

Low molecular weight heparin vs UFH

Recurrent VTE · patients with venous thromboembolism.

LMWH probably leads to lower incidence of recurrent VTE1 (3 months compared with UFH (moderate certainty).

2 findings from 1 review

Intervention not reported

Early postoperative non‐thrombotic complications · Individuals with peripheral arterial disease

The intervention showed no clear difference in early postoperative non‐thrombotic complications (high certainty).

1 finding from 1 review

Intervention not reported

Procedural mortality · Individuals with peripheral arterial disease

The intervention showed no clear difference in procedural mortality (high certainty).

1 finding from 1 review

Intervention not reported

Clinical improvement · Individuals with peripheral arterial disease

The intervention showed no clear difference in clinical improvement (low certainty).

1 finding from 1 review

Intervention not reported

Amputation · Individuals with peripheral arterial disease

The intervention showed no clear difference in amputation (high certainty).

1 finding from 1 review

Intervention not reported

Primary patency · Individuals with peripheral arterial disease

The intervention probably leads to higher primary patency (moderate certainty).

1 finding from 1 review

Intervention not reported

Primary patency · Individuals with peripheral arterial disease

The intervention showed no clear difference in primary patency (high certainty).

1 finding from 1 review

Intervention not reported

Mortality within · Individuals with peripheral arterial disease

The intervention showed no clear difference in mortality within (high certainty).

1 finding from 1 review

Low molecular weight heparin vs vitamin K antagonist (VKA)

Recurrent VTE · patients with symptomatic VTE requiring long term treatment (3 months) for symptomatic VTE

LMWH showed no clear difference in incidence of recurrent VTE (treatment duration 3 months) compared with VKA (moderate certainty).

1 finding from 1 review