Cochrane · systematic review · CD002001
Vitamin K antagonists versus low‐molecular‐weight heparin for the long term treatment of symptomatic venous thromboembolism
Andras, A, Sala Tenna, A, Stewart, M · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
VascularAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
3
current version
GRADE rated
3
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 1 · 33.3%Moderate 2 · 66.7%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
LMWH compared with VKA for long term treatment of symptomatic VTE
Population: patients with symptomatic VTE requiring long term treatment (3 months) for symptomatic VTE
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Incidence of recurrent VTE (treatment duration 3 months) LMWH vs VKA | Peto OR 0.83 [0.6, 1.15] | 16 studies · 3299 participants | Moderate Downgraded: risk of bias, imprecision |
Incidence of major bleeding (treatment duration 3 months) LMWH vs VKA | Peto OR 0.51 [0.32, 0.8] | 16 studies · 3299 participants | Low Downgraded: risk of bias, inconsistency |
Mortality (treatment duration 3 months) LMWH vs VKA | Peto OR 1.08 [0.75, 1.56] | 16 studies · 3299 participants | Moderate Downgraded: risk of bias, imprecision |