Cochrane · systematic review · CD001100
Fixed dose subcutaneous low molecular weight heparins versus adjusted dose unfractionated heparin for the initial treatment of venous thromboembolism
Robertson, L, Jones, LE · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
VascularAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 1 · 16.7%Moderate 5 · 83.3%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
LMWH compared to UFH for initial treatment of venous thromboembolism
Population: people with venous thromboembolism (VTE)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Incidence of recurrent VTE1 after initial treatment (up to 15 days) LMWH vs UFH | OR 0.69 [0.49, 0.98] | 18 studies · 6238 participants | Moderate Downgraded: risk of bias |
Incidence of recurrent VTE1 (3 months LMWH vs UFH | OR 0.71 [0.56, 0.9] | 16 studies · 6661 participants | Moderate Downgraded: risk of bias, imprecision |
Incidence of recurrent VTE1 (end of LMWH vs UFH | OR 0.72 [0.59, 0.88] | 22 studies · 9489 participants | Moderate Downgraded: risk of bias |
Reduction in thrombus size (pre‐ and post‐treatment venograms) LMWH vs UFH | OR 0.71 [0.61, 0.82] | 16 studies · 2909 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Incidence of major haemorrhagic episodes (during initial treatment ‐ up to 15 days) LMWH vs UFH | OR 0.69 [0.5, 0.95] | 25 studies · 8780 participants | Moderate Downgraded: risk of bias, imprecision |
Overall mortality (end of LMWH vs UFH | OR 0.84 [0.7, 1.01] | 24 studies · 9663 participants | Moderate Downgraded: risk of bias, imprecision |