Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,018 questions · 3,100 findings · 369 reviews · Headline outcomes only

No studies found 774 · 25%GRADE not reported 108 · 3.5%Very low 727 · 23.5%Low 840 · 27.1%Moderate 474 · 15.3%High 177 · 5.7%

Monotherapy vs combination therapy compared

Clinical failure—same beta lactam Antibiotic modifications · patients with sepsis

It is very uncertain whether monotherapy changes clinical failure—same beta lactam Antibiotic modifications compared with combination therapy compared (very low certainty).

1 finding from 1 review

Monotherapy vs combination therapy compared

Clinical failure—different beta lactam Antibiotic modifications · patients with sepsis

It is very uncertain whether monotherapy changes clinical failure—different beta lactam Antibiotic modifications compared with combination therapy compared (very low certainty).

1 finding from 1 review

Intervention not reported

"Moderate" benefit At least 30% reduction in pain · Adults with cancer pain

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Patient Global Impression of Change much or very much improved · Adults with cancer pain

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Patient‐reported disease‐specific symptom scores Symptom score with scale of 0 to 3 (0 = no symptoms, 3 = severe symptoms)

The intervention showed no clear difference in patient‐reported disease‐specific symptom scores Symptom score with… (low certainty).

1 finding from 1 review

Intervention not reported

Health‐related quality of life scores, measured by SF‐36 (range 0 to 100)

The intervention showed no clear difference in health‐related quality of life scores, measured by SF‐36 (range 0 to… (low certainty).

1 finding from 1 review

Intervention not reported

Endoscopic appearances 0 to 3 (0 = no polyps, 3 = severe polyposis)

The intervention showed no clear difference in endoscopic appearances 0 to 3 (0 = no polyps, 3 = severe polyposis) (low certainty).

1 finding from 1 review

Intervention not reported

All‐cause mortality or liver‐related morbidity · patients with chronic hepatitis C

It is very uncertain whether the intervention changes all‐cause mortality or liver‐related morbidity (very low certainty).

1 finding from 1 review

Intervention not reported

Adverse events · patients with chronic hepatitis C

The intervention showed no clear difference in adverse events (moderate certainty).

1 finding from 1 review

Intervention not reported

Failure of end of treatment virological response Absence of clearance of HCV RNA from the blood at end of treatment · patients with chronic hepatitis C

The intervention showed no clear difference in failure of end of treatment virological response Absence of… (moderate certainty).

1 finding from 1 review