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What do systematic reviews say?

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Evidence found and GRADE certainty

3,696 questions · 3,815 findings · 855 reviews

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No studies found 573 · 15%GRADE not reported 374 · 9.8%Very low 993 · 26%Low 1,062 · 27.8%Moderate 614 · 16.1%High 199 · 5.2%

Any ICS plus oral corticosteroid vs oral corticosteroid

Asthma relapse1at 20 to 24 days · predominantly adults with acute asthma following emergency department discharge

Any ICS plus oral corticosteroid showed no clear difference in asthma relapse1at 20 to 24 days compared with oral corticosteroid (high certainty).

1 finding from 1 review

Any ICS plus oral corticosteroid vs oral corticosteroid

Hoarseness at 20 to 24 days · predominantly adults with acute asthma following emergency department discharge

Any ICS plus oral corticosteroid showed no clear difference in hoarseness at 20 to 24 days compared with oral corticosteroid (moderate certainty).

1 finding from 1 review

Intervention not reported

On‐study mortality Death occurring up to 30 days after active study protocol · patients with cancer

The intervention leads to higher on‐study mortality Death occurring up to 30 days after active study… (high certainty).

1 finding from 1 review

Prophylactic platelet transfusion with one dose schedule vs prophylactic platelet transfusions with another dose schedule

Bleeding Number of days with significant bleeding ‐ Low dosage platelet transfusions versus standard dosage platelet transfusions · People with a haematological disorder
1 finding from 1 review

Prophylactic platelet transfusion with one dose schedule vs prophylactic platelet transfusions with another dose schedule

Bleeding: Number of days with significant bleeding ‐ High dosage platelet transfusions versus standard dosage platelet transfusions · People with a haematological disorder
1 finding from 1 review

Prophylactic platelet transfusion vs non prophylactic or therapeutic platelet transfusion

Bleeding: Number of days on which a significant bleeding event occurred3 · People with a haematological disorder

Prophylactic platelet transfusion showed no clear difference in bleeding: Number of days on which a significant bleeding event… compared with non prophylactic or therapeutic platelet transfusion (low certainty).

1 finding from 1 review

Intervention not reported

Analgesic consumption (day 2) post‐operative · Patients with haemorrhoids

The intervention probably leads to lower analgesic consumption (day 2) post‐operative (moderate certainty).

1 finding from 1 review

Human recombinant activated protein C vs placebo

28‐Day all‐cause mortality (adult and paediatric patients) · patients with severe sepsis or septic shock

Human recombinant activated protein C showed no clear difference in 28‐Day all‐cause mortality (adult and paediatric patients) compared with placebo (moderate certainty).

1 finding from 1 review

Human recombinant activated protein C vs placebo

Serious bleeding events in adult and paediatric patients (days 0 to 28) · patients with severe sepsis or septic shock

Human recombinant activated protein C probably leads to higher serious bleeding events in adult and paediatric patients (days 0 to… compared with placebo (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Recombinant activated factor VII vs placebo

Mortality within 5 days · patients with upper gastrointestinal bleeding and liver diseases.

Recombinant human factor VII activated showed no clear difference in mortality within 5 days compared with placebo (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Recombinant activated factor VII vs placebo

Mortality within 42 days · patients with upper gastrointestinal bleeding and liver diseases.

Recombinant human factor VII activated showed no clear difference in mortality within 42 days compared with placebo (moderate certainty).

1 finding from 1 review

Social cognitive theory for promotion of condom use vs no intervention

Consistent application of condom by FSWs · sex workers

Social cognitive theory for promotion of condom use showed no clear difference in consistent condom use by FSWs with clients in the past 7‐day compared with no intervention (moderate certainty).

1 finding from 1 review