Gap finder

Search review questions

Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Every word you type has to appear somewhere in the question, and the closest matches are ranked first.

Limit to evidence status or GRADE (optional)

75,239 questions in 5,342 reviews

current versions
No studies 15,213 · 20.2%Ungraded 10,323 · 13.7%Very low 17,528 · 23.3%Low 17,951 · 23.9%Moderate 11,190 · 14.9%High 3,034 · 4%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

QuestionEffectEvidenceStatus / GRADE
Intervention NR
Reduction in salivary flow
Interventions for drooling in children with cerebral palsy (2012) · Cochrane
no estimate extractedNRLow
Intervention NR
Reduction in frequency and severity of drooling
Interventions for drooling in children with cerebral palsy (2012) · Cochrane
no estimate extractedNRLow
Intervention NR
Adverse Effects to BoNT‐A
Interventions for drooling in children with cerebral palsy (2012) · Cochrane
no estimate extractedNRLow
Intervention NR
Non‐compliance with intervention
Interventions for drooling in children with cerebral palsy (2012) · Cochrane
no estimate extractedNRLow
Intervention NR
Reduction in salivary flow
Interventions for drooling in children with cerebral palsy (2012) · Cochrane
no estimate extractedNRLow
Intervention NR
Reduction in frequency and severity of drooling
Interventions for drooling in children with cerebral palsy (2012) · Cochrane
no estimate extractedNRLow
Intervention NR
Adverse effects of benztropine
Interventions for drooling in children with cerebral palsy (2012) · Cochrane
no estimate extractedNRLow
Intervention NR
Adverse effects of glycopyrrolate
Interventions for drooling in children with cerebral palsy (2012) · Cochrane
no estimate extractedNRLow
Intervention NR
Non‐compliance with intervention
Interventions for drooling in children with cerebral palsy (2012) · Cochrane
no estimate extractedNRLow
Intervention NR
All‐cause mortality · overweight or obese adults
Green tea for weight loss and weight maintenance in overweight or obese adults (2012) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Morbidity · overweight or obese adults
Green tea for weight loss and weight maintenance in overweight or obese adults (2012) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Health‐related quality of life · overweight or obese adults
Green tea for weight loss and weight maintenance in overweight or obese adults (2012) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Patient satisfaction · overweight or obese adults
Green tea for weight loss and weight maintenance in overweight or obese adults (2012) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Adverse effects 12 to 13 weeks · overweight or obese adults
Green tea for weight loss and weight maintenance in overweight or obese adults (2012) · Cochrane
no estimate extractedNRVery low
Intervention NR
Weight loss (change in kg) · overweight or obese adults
Green tea for weight loss and weight maintenance in overweight or obese adults (2012) · Cochrane
no estimate extracted6 studies · 532 participantsModerate
Intervention NR
Costs · overweight or obese adults
Green tea for weight loss and weight maintenance in overweight or obese adults (2012) · Cochrane
no estimate extractedNRNo studies
Febuxostat 40 mg/day vs placebo
Incidence of gout flares · patients with chronic gout
Febuxostat for treating chronic gout (2012) · Cochrane
RR 0.95 [0.52, 1.7]1 study · 75 participantsLow
Febuxostat 80 mg/day vs placebo
Pain · patients with chronic gout
Febuxostat for treating chronic gout (2012) · Cochrane
no estimate extractedNRNo studies
Febuxostat 80 mg/day vs placebo
Patient global assessment · patients with chronic gout
Febuxostat for treating chronic gout (2012) · Cochrane
no estimate extractedNRNo studies
Febuxostat 80 mg/day vs placebo
Health Related Quality of Life · patients with chronic gout
Febuxostat for treating chronic gout (2012) · Cochrane
no estimate extractedNRNo studies
Febuxostat 80 mg/day vs placebo
Serious Adverse Events · patients with chronic gout
Febuxostat for treating chronic gout (2012) · Cochrane
RR 2.8 [0.72, 10.7]2 studies · 479 participantsModerate
Febuxostat 80 mg/day vs placebo
Discontinuations due to adverse events · patients with chronic gout
Febuxostat for treating chronic gout (2012) · Cochrane
RR 1.8 [0.74, 4.5]2 studies · 479 participantsModerate
Febuxostat 120 mg/day vs placebo
Incidence of gout flares · patients with chronic cout
Febuxostat for treating chronic gout (2012) · Cochrane
RR 1.7 [1.3, 2.3]2 studies · 479 participantsModerate
Febuxostat 120 mg/day vs placebo
Serum uric acid <6.0 mg/dL at final visit · patients with chronic cout
Febuxostat for treating chronic gout (2012) · Cochrane
RR 80.7 [16, 405.5]2 studies · 356 participantsLow
Febuxostat 120 mg/day vs placebo
Pain · patients with chronic cout
Febuxostat for treating chronic gout (2012) · Cochrane
no estimate extractedNRNo studies
Febuxostat 120 mg/day vs placebo
Patient global assessment · patients with chronic cout
Febuxostat for treating chronic gout (2012) · Cochrane
no estimate extractedNRNo studies
Febuxostat 120 mg/day vs placebo
Health Related Quality of Life · patients with chronic cout
Febuxostat for treating chronic gout (2012) · Cochrane
no estimate extractedNRNo studies
Febuxostat 40 mg/day vs placebo
Serum uric acid <6.0 mg/dL at final visit · patients with chronic gout
Febuxostat for treating chronic gout (2012) · Cochrane
RR 40.1 [2.5, 639.1]1 study · 69 participantsLow
Febuxostat 120 mg/day vs placebo
Serious Adverse events · patients with chronic cout
Febuxostat for treating chronic gout (2012) · Cochrane
RR 2.7 [0.7, 10.2]2 studies · 479 participantsModerate
Febuxostat 120 mg/day vs placebo
Discontinuations due to adverse events · patients with chronic cout
Febuxostat for treating chronic gout (2012) · Cochrane
RR 1.7 [0.67, 4.1]2 studies · 479 participantsModerate
Febuxostat 40 mg/day vs allopurinol
Incidence of gout flares · patients with chronic gout
Febuxostat for treating chronic gout (2012) · Cochrane
RR 0.97 [0.57, 1.65]1 study · 1324 participantsHigh
Febuxostat 40 mg/day vs allopurinol
Serum uric acid <6.0 mg/dL at final visit · patients with chronic gout
Febuxostat for treating chronic gout (2012) · Cochrane
RR 1.1 [0.94, 1.2]1 study · 1324 participantsModerate
Febuxostat 40 mg/day vs allopurinol
Pain · patients with chronic gout
Febuxostat for treating chronic gout (2012) · Cochrane
no estimate extractedNRNo studies
Febuxostat 40 mg/day vs allopurinol
Patient global assessment · patients with chronic gout
Febuxostat for treating chronic gout (2012) · Cochrane
no estimate extractedNRNo studies
Febuxostat 40 mg/day vs allopurinol
Health Related Quality of Life · patients with chronic gout
Febuxostat for treating chronic gout (2012) · Cochrane
no estimate extractedNRNo studies
Febuxostat 40 mg/day vs allopurinol
Serious Adverse Events · patients with chronic gout
Febuxostat for treating chronic gout (2012) · Cochrane
RR 0.61 [0.35, 1.07]1 study · 1513 participantsHigh
Febuxostat 40 mg/day vs allopurinol
Discontinuations due to adverse events · patients with chronic gout
Febuxostat for treating chronic gout (2012) · Cochrane
RR 1.2 [0.9, 1.7]1 study · 1513 participantsHigh
Febuxostat 80 mg/day vs allopurinol
Incidence of gout flares · patients with chronic gout
Febuxostat for treating chronic gout (2012) · Cochrane
RR 1.1 [0.98, 1.3]3 studies · 2325 participantsHigh
Febuxostat 40 mg/day vs placebo
Pain · patients with chronic gout
Febuxostat for treating chronic gout (2012) · Cochrane
no estimate extractedNRNo studies
Febuxostat 80 mg/day vs allopurinol
Serum uric acid <6.0 mg/dL at final visit · patients with chronic gout
Febuxostat for treating chronic gout (2012) · Cochrane
RR 1.8 [1.6, 2.2]3 studies · 2193 participantsLow
Febuxostat 80 mg/day vs allopurinol
Pain · patients with chronic gout
Febuxostat for treating chronic gout (2012) · Cochrane
no estimate extractedNRNo studies
Febuxostat 80 mg/day vs allopurinol
Patient global assessment · patients with chronic gout
Febuxostat for treating chronic gout (2012) · Cochrane
no estimate extractedNRNo studies
Febuxostat 80 mg/day vs allopurinol
Health Related Quality of Life · patients with chronic gout
Febuxostat for treating chronic gout (2012) · Cochrane
no estimate extractedNRNo studies
Febuxostat 80 mg/day vs allopurinol
Serious Adverse Events · patients with chronic gout
Febuxostat for treating chronic gout (2012) · Cochrane
RR 0.91 [0.34, 2.4]3 studies · 1044 participantsModerate
Febuxostat 80 mg/day vs allopurinol
Discontinuations due to adverse events · patients with chronic gout
Febuxostat for treating chronic gout (2012) · Cochrane
RR 1.3 [0.79, 2.1]3 studies · 1044 participantsModerate
Febuxostat 120 mg/day vs allopurinol
Incidence of gout flares · patients with chronic gout
Febuxostat for treating chronic gout (2012) · Cochrane
RR 1.3 [0.87, 1.9]2 studies · 986 participantsHigh
Febuxostat 120 mg/day vs allopurinol
Serum uric acid <6.0 mg/dL at final visit · patients with chronic gout
Febuxostat for treating chronic gout (2012) · Cochrane
RR 2.2 [1.9, 2.5]2 studies · 880 participantsModerate
Febuxostat 120 mg/day vs allopurinol
Pain · patients with chronic gout
Febuxostat for treating chronic gout (2012) · Cochrane
no estimate extractedNRNo studies
Febuxostat 120 mg/day vs allopurinol
Patient global assessment · patients with chronic gout
Febuxostat for treating chronic gout (2012) · Cochrane
no estimate extractedNRNo studies
Febuxostat 40 mg/day vs placebo
Patient global assessment · patients with chronic gout
Febuxostat for treating chronic gout (2012) · Cochrane
no estimate extractedNRNo studies