Pembrolizumab showed no clear difference in treatment‐related mortality compared with chemotherapy (low certainty).
Pembrolizumab showed no clear difference in discontinuation due to adverse event compared with chemotherapy (low certainty).
Pembrolizumab may leads to lower serious adverse events (irrespective of attribution to treatment) compared with chemotherapy (low certainty).
Standard care plus IV tranexamic acid showed no clear difference in maternal mortality due to bleeding compared with placebo or standard care alone (moderate certainty).
Standard care plus IV tranexamic acid showed no clear difference in maternal mortality (all causes) compared with placebo or standard care alone (moderate certainty).
Standard care plus IV tranexamic acid showed no clear difference in serious maternal morbidity (any) compared with placebo or standard care alone (high certainty).
Standard care plus IV tranexamic acid may leads to lower blood loss 500 mL or more after randomisation compared with placebo or standard care alone (low certainty).
Standard care plus IV tranexamic acid showed no clear difference in blood transfusion (any) compared with placebo or standard care alone (moderate certainty).
Standard care plus IV tranexamic acid showed no clear difference in surgical intervention to control bleeding: Hysterectomy compared with placebo or standard care alone (high certainty).
Standard care plus IV tranexamic acid showed no clear difference in side effects of the intervention: Any maternal vascular occlusive… compared with placebo or standard care alone (moderate certainty).
Metformin showed no clear difference in live birth rate per woman compared with placebo or no treatment (low certainty).
The review found no eligible studies for this question.
Metformin combined with clomiphene citrate probably leads to higher ovulation rate per woman compared with clomiphene citrate alone (moderate certainty).
Metformin combined with clomiphene citrate may leads to higher miscarriage rate per woman compared with clomiphene citrate alone (low certainty).
It is very uncertain whether metformin changes live birth rate per woman Participants with BMI < 30 kg/m2 or ≤ 32… compared with clomiphene citrate (very low certainty).
It is very uncertain whether metformin changes live birth rate per woman Participants with BMI ≥ 30 kg/m2a compared with clomiphene citrate (very low certainty).
The review found no eligible studies for this question.
It is very uncertain whether metformin changes clinical pregnancy rate per woman Participants with BMI < 30 kg/m2… compared with clomiphene citrate (very low certainty).
It is very uncertain whether metformin changes clinical pregnancy rate per woman Participants with BMI ≥ 30 kg/m2a compared with clomiphene citrate (very low certainty).
The review found no eligible studies for this question.