Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

285 questions · 301 findings · 29 reviews

No studies found 51 · 16.9%GRADE not reported 20 · 6.6%Very low 91 · 30.2%Low 80 · 26.6%Moderate 50 · 16.6%High 9 · 3%

Any intervention vs steroid alone or plus levofloxacin

Proportion of initially unaffected fellow eyes that had signs/symptoms of infection within 7 days of onset of signs/symptoms in the first eye (lower is favored) · epidemic keratoconjunctivitis

The review found no eligible studies for this question.

1 finding from 1 review

Systemic (oral) betamethasone vs Topical triamcinolone acetonide paste

Clinical score · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

It is very uncertain whether systemic (oral) betamethasone changes clinical score compared with topical triamcinolone acetonide paste (very low certainty).

1 finding from 1 review

Systemic (oral) betamethasone vs Topical triamcinolone acetonide paste

Pain resolution · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

It is very uncertain whether systemic (oral) betamethasone changes pain resolution compared with topical triamcinolone acetonide paste (very low certainty).

1 finding from 1 review

Ketoconazole vs steroids

Failure to achieve complete resolution (combined for face and scalp) Clinical assessment · patients with seborrhoeic dermatitis

Ketoconazole showed no clear difference in failure to achieve complete resolution (combined for face and scalp)… compared with steroids (low certainty).

1 finding from 1 review

Ketoconazole vs steroids

Side effects (combined for face and scalp) Self report · patients with seborrhoeic dermatitis

Ketoconazole probably leads to lower side effects (combined for face and scalp) Self report compared with steroids (moderate certainty).

1 finding from 1 review

Tacrolimus 0.1% vs corticosteroids

Physician's assessment of global response of improvement, clear or excellent ‐ 6 weeks · people with atopic dermatitis

Tacrolimus 0.1% probably leads to higher physician's assessment of global response of improvement, clear or… compared with corticosteroids (moderate certainty).

3 findings from 1 review

Tacrolimus 0.03% vs corticosteroids

Participant's self‐assessment of global response of improvement: tacrolimus 0.03% 2x/day versus hydrocortisone acetate 1% 2x/day · people with atopic dermatitis

Tacrolimus 0.03% probably leads to higher participant's self‐assessment of global response of improvement:… compared with corticosteroids (moderate certainty).

1 finding from 1 review

Tacrolimus 0.1% vs corticosteroids

Adverse effects ‐ burning · people with atopic dermatitis

Tacrolimus 0.1% probably leads to higher adverse effects: burning ‐ tacrolimus 0.1% versus hydrocortisone… compared with corticosteroids (moderate certainty).

3 findings from 1 review

Tacrolimus 0.1% vs corticosteroids

Participant's self‐assessment of global response of improvement · people with atopic dermatitis

Tacrolimus 0.1% may leads to higher participant's self‐assessment of global response of improvement compared with corticosteroids (low certainty).

1 finding from 1 review

Azoles vs moderate‐potent corticosteroid/azole combinations

Clinical cure · patients with tinea cruris and tinea corporis

It is very uncertain whether azoles changes clinical cure (immediately at end of treatment) Resolution of… compared with moderate‐potent corticosteroid/azole combinations (very low certainty).

1 finding from 1 review

Azoles vs moderate‐potent corticosteroid/azole combinations

Adverse effects Reported by investigators 'and' or 'or' participants · patients with tinea cruris and tinea corporis

It is very uncertain whether azoles changes adverse effects Reported by investigators 'and' or 'or' participants compared with moderate‐potent corticosteroid/azole combinations (very low certainty).

1 finding from 1 review