Cochrane · systematic review · CD013520
Topical pharmacologic interventions versus placebo for epidemic keratoconjunctivitis
Liu, S-H, Hawkins, BS, Ng, SM, et al. · Cochrane Database of Systematic Reviews · 2022 · Cochrane Library
Eyes and VisionAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
24
current version
GRADE rated
17
No studies
7
Included studies
NR
No studies 7 · 29.2%Ungraded 0 · 0%Very low 15 · 62.5%Low 2 · 8.3%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Any intervention compared with artificial tears or saline
Population: epidemic keratoconjunctivitis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mean number of days from treatment initiation to resolution of symptoms or signs (shorter is favored) Any intervention vs artificial tears or saline | no estimate extracted | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
Proportion of participants with resolution of symptoms within 10 days of treatment (higher is favored) Any intervention vs artificial tears or saline | RR 1.15 [1.07, 1.24] | 2 studies · 409 participants | Low Downgraded: risk of bias, imprecision |
Proportion of participants with resolution of signs within 10 days of treatment (higher is favored) Any intervention vs artificial tears or saline | 3.19 [2.29, 4.45] | 2 studies · 409 participants | Low Downgraded: risk of bias, imprecision |
Proportion of participants in whose eyes SEIs had developed within 30 days of treatment initiation (lower is favored) Any intervention vs artificial tears or saline | RR 0.24 [0.1, 0.56] | 2 studies · 77 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Proportion of participants in whose eyes SEI had disappeared within 21 days of treatment (higher is favored) Any intervention vs artificial tears or saline | RR 1.34 [0.88, 2.04] | 2 studies · 156 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Proportion of participants who discontinued medication and did not develop rebound SEI within 21 days (higher is favored) Any intervention vs artificial tears or saline | no estimate extracted | NR | No studies |
Proportion of participants who had evidence of adenoviral eradication within 14 days of treatment (higher is favored) Any intervention vs artificial tears or saline | no estimate extracted | NR | Very low Downgraded: risk of bias, imprecision, indirectness |
Proportion of initially unaffected fellow eyes that had signs/symptoms of infection within 7 days of onset of signs/symptoms in the first eye (lower is favored) Any intervention vs artificial tears or saline | no estimate extracted | NR | No studies |
Any intervention compared with steroid alone or plus levofloxacin
Population: epidemic keratoconjunctivitis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mean number of days from treatment initiation to resolution of symptoms or signs (shorter is favored) Any intervention vs steroid alone or plus levofloxacin | no estimate extracted | NR | Very low Downgraded: risk of bias, imprecision, indirectness |
Proportion of participants with resolution of symptoms within 7 days of treatment (higher is favored) Any intervention vs steroid alone or plus levofloxacin | no estimate extracted | NR | Very low Downgraded: risk of bias, imprecision, indirectness |
Proportion of participants with resolution of signs within 7 days of treatment (higher is favored) Any intervention vs steroid alone or plus levofloxacin | no estimate extracted | NR | Very low Downgraded: risk of bias, imprecision, indirectness |
Proportion of eyes in which SEI had developed within 21 days of treatment (lower is favored) Any intervention vs steroid alone or plus levofloxacin | RR 0.08 [0.01, 0.55] | 2 studies · 69 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Proportion of participants in whose eyes SEI had disappeared within 4 weeks of treatment initiation (higher is favored) Any intervention vs steroid alone or plus levofloxacin | no estimate extracted | NR | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Proportion of participants who discontinued medication and did not develop rebound SEI within 21 days (higher is favored) Any intervention vs steroid alone or plus levofloxacin | RR 1.04 [0.94, 1.14] | 3 studies · 231 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Proportion of participants who had evidence of adenoviral eradication by day 14 after initiation of treatment (higher is favored) Any intervention vs steroid alone or plus levofloxacin | no estimate extracted | NR | Very low Downgraded: risk of bias, imprecision, indirectness |
Proportion of initially unaffected fellow eyes that had signs/symptoms of infection within 7 days of onset of signs/symptoms in the first eye (lower is favored) Any intervention vs steroid alone or plus levofloxacin | no estimate extracted | NR | No studies |
Topical steroid compared with artificial tears
Population: epidemic keratoconjunctivitis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mean number of days from treatment initiation to resolution of symptoms or signs (shorter is favored) Topical steroid vs artificial tears | no estimate extracted | 1 study · 50 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Proportion of participants with resolution of symptoms within 7 days of treatment (higher is favored) Topical steroid vs artificial tears | RR 1 [0.07, 15.15] | 1 study · 52 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Proportion of participants with resolution of signs within 7 days of treatment (higher is favored) Topical steroid vs artificial tears | no estimate extracted | NR | No studies |
Proportion of participants in whose eyes SEI had developed within 21 days of treatment (lower is favored) Topical steroid vs artificial tears | RR 2.2 [0.89, 5.41] | 1 study · 50 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Proportion of participants in whose eyes SEI had disappeared within 21 days of treatment initiation (higher is favored) Topical steroid vs artificial tears | no estimate extracted | NR | No studies |
Proportion of participants who discontinued medication and did not develop rebound SEI within 21 days (higher is favored) Topical steroid vs artificial tears | no estimate extracted | NR | No studies |
Proportion of participants who had evidence of adenoviral eradication within 14 days of treatment (higher is favored) Topical steroid vs artificial tears | no estimate extracted | 1 study · 50 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Proportion of initially unaffected fellow eyes that had signs/symptoms of infection within 7 days of onset of signs/symptoms in the first eye (lower is favored) Topical steroid vs artificial tears | no estimate extracted | NR | No studies |