Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

300 questions · 309 findings · 40 reviews

No studies found 46 · 14.9%GRADE not reported 6 · 1.9%Very low 97 · 31.4%Low 83 · 26.9%Moderate 57 · 18.4%High 20 · 6.5%

Ultrasound‐accelerated thrombolysis vs thrombolysis alone

Clinical success ‐ increase in ABI by at least 0.2 · adults with ALI

It is very uncertain whether ultrasound‐accelerated thrombolysis changes clinical success ‐ increase in ABI by at least 0.2 compared with thrombolysis alone (very low certainty).

1 finding from 1 review

Endovascular therapy plus conventional medical treatment vs medical treatment

Death or stroke · people with vertebral artery stenosis

Endovascular treat ment plus medical treatment showed no clear difference in 30‐day post‐randomisation death/stroke compared with medical treatment alone (low certainty).

1 finding from 1 review

Endovascular therapy plus conventional medical treatment vs medical treatment

Fatal/non‐fatal stroke in the territory of the treated vertebral artery stenosis(assessed after 30 days post‐randomisation to completion of · people with vertebral artery stenosis

Endovascular treat ment plus medical treatment showed no clear difference in fatal/non‐fatal stroke in the territory of the treated vertebral… compared with medical treatment alone (moderate certainty).

1 finding from 1 review

Endovascular therapy plus conventional medical treatment vs medical treatment

Stroke (ischaemic or haemorrhagic)Median · people with vertebral artery stenosis

Endovascular treat ment plus medical treatment showed no clear difference in stroke (ischaemic or haemorrhagic)Median compared with medical treatment alone (moderate certainty).

1 finding from 1 review

Intervention not reported

Proportion of participants who experienced operative or postoperative serious adverse events · patients with multiple sclerosis and chronic cerebrospinal venous insufficiency (CCSVI)

The intervention showed no clear difference in proportion of participants who experienced operative or… (moderate certainty).

1 finding from 1 review

Intervention not reported

Proportion of participants who experienced improvement of composite functional endpoint over 12 months · patients with multiple sclerosis and chronic cerebrospinal venous insufficiency (CCSVI)

The intervention showed no clear difference in proportion of participants who experienced improvement of composite… (moderate certainty).

1 finding from 1 review

Intervention not reported

Proportion of participants who experienced new relapses over 12 months · patients with multiple sclerosis and chronic cerebrospinal venous insufficiency (CCSVI)

The intervention showed no clear difference in proportion of participants who experienced new relapses over 12 months (moderate certainty).

1 finding from 1 review

Intervention not reported

Participant global assessment of success (People perceived their pain as better) · people with osteoporotic vertebral compression fracture

The intervention showed no clear difference in participant global assessment of success (People perceived their… (moderate certainty).

1 finding from 1 review

Intervention not reported

Incident symptomatic vertebral fractures · people with osteoporotic vertebral compression fracture

The intervention showed no clear difference in incident symptomatic vertebral fractures (low certainty).

1 finding from 1 review

Intervention not reported

Other serious adverse events · people with osteoporotic vertebral compression fracture

The intervention showed no clear difference in other serious adverse events (low certainty).

1 finding from 1 review