Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

285 questions · 327 findings · 36 reviews · Headline outcomes only

No studies found 129 · 39.4%GRADE not reported 11 · 3.4%Very low 82 · 25.1%Low 64 · 19.6%Moderate 38 · 11.6%High 3 · 0.9%

Low‐ vs high‐energy diode trans‐scleral cyclophotocoagulation

Control of intraocular pressure · people with primary open‐angle glaucoma and no previous glaucoma surgery

Low‐ showed no clear difference in control of intraocular pressure compared with high‐energy diode trans‐scleral cyclophotocoagulation (low certainty).

1 finding from 1 review

Low tidal volume vs high tidal volume

All‐cause mortality · adults (aged > 16 years) without acute lung injury needing mechanical positive pressure ventilation during their surgery and undergoing…

Low tidal volume showed no clear difference in mortality compared with high tidal volume (low certainty).

1 finding from 1 review

Low tidal volume vs high tidal volume

Pneumonia · adults (aged > 16 years) without acute lung injury needing mechanical positive pressure ventilation during their surgery and undergoing…

Low tidal volume probably leads to lower pneumonia compared with high tidal volume (moderate certainty).

1 finding from 1 review

Low tidal volume vs high tidal volume

Need for postoperative non‐invasive ventilatory support · adults (aged > 16 years) without acute lung injury needing mechanical positive pressure ventilation during their surgery and undergoing…

Low tidal volume probably leads to lower need for postoperative non‐invasive ventilatory support compared with high tidal volume (moderate certainty).

1 finding from 1 review

Low tidal volume vs high tidal volume

Need for postoperative invasive ventilatory support · adults (aged > 16 years) without acute lung injury needing mechanical positive pressure ventilation during their surgery and undergoing…

Low tidal volume probably leads to lower need for postoperative invasive ventilatory support compared with high tidal volume (moderate certainty).

1 finding from 1 review

Low tidal volume vs high tidal volume

Barotrauma (pneumothorax) · adults (aged > 16 years) without acute lung injury needing mechanical positive pressure ventilation during their surgery and undergoing…

It is very uncertain whether low tidal volume changes barotrauma: pneumothorax compared with high tidal volume (very low certainty).

1 finding from 1 review