Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,271 questions · 1,326 findings · 329 reviews

No studies found 247 · 18.6%GRADE not reported 237 · 17.9%Very low 379 · 28.6%Low 285 · 21.5%Moderate 141 · 10.6%High 37 · 2.8%

Rituximab vs intravenous methylprednisolone

NOSPECS improvement (decrease) by 2 classes or more · thyroid‐associated ophthalmopathy

It is very uncertain whether summary of findings table ‐ Rituximab changes NOSPECS improvement (decrease) by 2 or more classes compared with intravenous methylprednisolone (very low certainty).

1 finding from 1 review

Rituximab vs intravenous methylprednisolone

Proptosis improvement (decrease) by 2 mm or more · thyroid‐associated ophthalmopathy

It is very uncertain whether summary of findings table ‐ Rituximab changes proptosis improvement (decrease) by 2 mm or more compared with intravenous methylprednisolone (very low certainty).

1 finding from 1 review

Rituximab vs intravenous methylprednisolone

Palpebral aperture improvement (decrease) by 3 mm or more · thyroid‐associated ophthalmopathy

It is very uncertain whether summary of findings table ‐ Rituximab changes palpebral aperture improvement (decrease) by 3 mm or more compared with intravenous methylprednisolone (very low certainty).

1 finding from 1 review

Rituximab vs intravenous methylprednisolone

Motility improvement (increase) by 1 class or more · thyroid‐associated ophthalmopathy

It is very uncertain whether summary of findings table ‐ Rituximab changes motility improvement (increase) by 1 class or more compared with intravenous methylprednisolone (very low certainty).

1 finding from 1 review

Rituximab vs placebo

CAS improvement (decrease) by 2 or more points · thyroid‐associated ophthalmopathy

It is very uncertain whether summary of findings table ‐ Rituximab changes CAS improvement (decrease) by 2 or more points compared with placebo (very low certainty).

1 finding from 1 review

Rituximab vs placebo

NOSPECS improvement (decrease) by 2 classes or more · thyroid‐associated ophthalmopathy

It is very uncertain whether summary of findings table ‐ Rituximab changes NOSPECS improvement (decrease) by 2 classes or more compared with placebo (very low certainty).

1 finding from 1 review

Binocular iPad treatment vs occlusion therapy

Measurable change in stereopsis after 8 (± 2) weeks and 16 (± 2) weeks of intervention 'Real change' in stereopsis is defined as a change in stereoacuity of two or more octaves. · 5‐ to 8‐year‐old children with amblyopia

The review found no eligible studies for this question.

1 finding from 1 review

Exercise vs control

Number of people who experienced one or more falls · people with Parkinson's disease

Summary of findings for exercise showed no clear difference in number of people who experienced one or more falls compared with control (moderate certainty).

1 finding from 1 review

Summary of findings for exercise plus education vs control

Number of people sustaining one or more fall‐related fractures · people with Parkinson's disease

It is very uncertain whether summary of findings for exercise plus education changes number of people sustaining one or more fall‐related fractures compared with control (very low certainty).

1 finding from 1 review

Exercise vs control

Number of people sustaining one or more fall‐related fractures · people with Parkinson's disease

It is very uncertain whether summary of findings for exercise changes number of people sustaining one or more fall‐related fractures compared with control (very low certainty).

1 finding from 1 review

Weekend therapy vs no topical corticosteroids

Clinician‐reported signs of eczema: number of participants with one or more relapses (16‐20 weeks) · children and adults with mild to severe eczema

Weekend therapy probably leads to lower clinician‐reported signs of eczema: number of participants with one… compared with no topical corticosteroid (moderate certainty).

1 finding from 1 review