Findings

What do systematic reviews say?

Refine by population, intervention, comparison or outcome
More filters
Evidence found and GRADE certainty

334 questions · 337 findings · 56 reviews

No studies found 77 · 22.8%GRADE not reported 5 · 1.5%Very low 113 · 33.5%Low 75 · 22.3%Moderate 61 · 18.1%High 6 · 1.8%

Tranexamic acid vs placebo (saline solution or sterile water)

Significant adverse events (seizures, thromboembolism) within 24 hours of surgery) · adults and children with chronic rhinosinusitis with or without nasal polyps

Tranexamic acid showed no clear difference in significant adverse events (seizures, thromboembolism) within 24… compared with placebo (saline solution or sterile water) (moderate certainty).

1 finding from 1 review

Tranexamic acid vs placebo (saline solution or sterile water)

Overall rate of surgical complications · adults and children with chronic rhinosinusitis with or without nasal polyps

Tranexamic acid showed no clear difference in surgical complications compared with placebo (saline solution or sterile water) (moderate certainty).

1 finding from 1 review

Tranexamic acid vs placebo (saline solution or sterile water)

Postoperative bleeding (place of packing or revision surgery within 14 days of surgery) · adults and children with chronic rhinosinusitis with or without nasal polyps

Tranexamic acid showed no clear difference in postoperative bleeding (place of packing or revision surgery within… compared with placebo (saline solution or sterile water) (low certainty).

1 finding from 1 review

Guidewire‐assisted cannulation vs contrast‐assisted cannulation

Post‐ERCP pancreatitis · Patients undergoing diagnostic or therapeutic ERCP

Guidewire‐assisted cannulation probably leads to lower post‐ERCP pancreatitis (PEP) compared with contrast‐assisted cannulation (moderate certainty).

1 finding from 1 review

Guidewire‐assisted cannulation vs contrast‐assisted cannulation

Primary cannulation success · Patients undergoing diagnostic or therapeutic ERCP

Guidewire‐assisted cannulation may leads to higher primary cannulation success compared with contrast‐assisted cannulation (low certainty).

1 finding from 1 review

Guidewire‐assisted cannulation vs contrast‐assisted cannulation

Overall success of cannulation · Patients undergoing diagnostic or therapeutic ERCP

Guidewire‐assisted cannulation showed no clear difference in overall cannulation success compared with contrast‐assisted cannulation (moderate certainty).

1 finding from 1 review

Guidewire‐assisted cannulation vs contrast‐assisted cannulation

Need for precut sphincterotomy · Patients undergoing diagnostic or therapeutic ERCP

Guidewire‐assisted cannulation probably leads to lower need for precut sphincterotomy compared with contrast‐assisted cannulation (moderate certainty).

1 finding from 1 review

Guidewire‐assisted cannulation vs contrast‐assisted cannulation

Post‐sphincterotomy bleeding · Patients undergoing diagnostic or therapeutic ERCP

Guidewire‐assisted cannulation showed no clear difference in post‐sphincterotomy bleeding compared with contrast‐assisted cannulation (low certainty).

1 finding from 1 review

Guidewire‐assisted cannulation vs contrast‐assisted cannulation

Perforation · Patients undergoing diagnostic or therapeutic ERCP

It is very uncertain whether guidewire‐assisted cannulation changes perforation compared with contrast‐assisted cannulation (very low certainty).

1 finding from 1 review

Intervention not reported

Overall morbidity (30‐day postoperative; procedure‐ and non‐procedure related) · patients with stones in the gallbladder and common bile duct undergoing laparoscopic cholecystectomy

The intervention showed no clear difference in overall morbidity (30‐day postoperative; procedure‐ and… (low certainty).

1 finding from 1 review