Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

344 questions · 346 findings · 97 reviews · Headline outcomes only

No studies found 31 · 9%GRADE not reported 6 · 1.7%Very low 154 · 44.5%Low 99 · 28.6%Moderate 39 · 11.3%High 17 · 4.9%

Heparin prophylaxis vs no treatment/placebo

Symptomatic DVT · pregnant women at increased risk of VTE during pregnancy and the early postnatal period

It is very uncertain whether antenatal (± postnatal) prophylaxis: heparin (LMWH or UFH) changes symptomatic DVT ( compared with no treatment/placebo (very low certainty).

1 finding from 1 review

ENZYME INHIBITOR ‐ VMAT2‐INHIBITOR (valbenazine) vs placebo

Leaving the study early · 18 to 85 year‐old patients with schizophrenia, schizoaffective disorder, mood disorder, or gastrointestinal disorder +…

It is very uncertain whether ENZYME INHIBITOR ‐ VMAT2‐INHIBITOR (valbenazine) changes leaving the study early compared with PLACEBO (very low certainty).

1 finding from 1 review

Laparoscopy vs laparotomy

Overall survival (survival until death from all causes) · adult women diagnosed with early stage (I to IIa) endometrial cancer undergoing surgery as primary treatment.

Laparoscopy showed no clear difference in overall survival (survival until death from all causes) compared with laparotomy (moderate certainty).

1 finding from 1 review

Laparoscopy vs laparotomy

Serious adverse events (range of outcomes) · adult women diagnosed with early stage (I to IIa) endometrial cancer undergoing surgery as primary treatment.

Laparoscopy showed no clear difference in serious adverse events (range of outcomes) compared with laparotomy (low certainty).

1 finding from 1 review

HALOPERIDOL vs first‐generation antipsychotics

Behaviour: Leaving the study early (short‐term) · patients with schizophrenia

Haloperidol showed no clear difference in leaving the study early due to any reason as a measure of overall… compared with first‐generation antipsychotics (low certainty).

1 finding from 1 review

HALOPERIDOL vs first‐generation antipsychotics

Leaving the study early ‐ due to adverse effects (short term) · patients with schizophrenia

It is very uncertain whether haloperidol changes leaving the study early due to adverse events as a measure of… compared with first‐generation antipsychotics (very low certainty).

1 finding from 1 review

HALOPERIDOL vs first‐generation antipsychotics

Leaving the study early ‐ medium term ‐ any reason · patients with schizophrenia

It is very uncertain whether haloperidol changes leaving the study early due to any reason as a measure of overall… compared with first‐generation antipsychotics (very low certainty).

1 finding from 1 review

SPECIALISED TEAM vs usual care

Compliance with treatment ‐ treatment stopped in spite of need ‐ by one year · people with psychosis

SPECIALISED TEAM probably leads to lower compliance with treatment ‐ treatment stopped in spite of need ‐ by… compared with STANDARD CARE (moderate certainty).

1 finding from 1 review