Riluzole vs placebo
Severe adverse events attributable to treatment · children with SMA type I
1 finding from 1 review
- no estimate extracted1 study · 10 participantsVery low
Findings
What do systematic reviews say?
1,138 questions · 1,154 findings · 139 reviews · Headline outcomes only
No studies found 184 · 15.9%GRADE not reported 183 · 15.9%Very low 273 · 23.7%Low 296 · 25.6%Moderate 171 · 14.8%High 47 · 4.1%
Intrathecal injected nusinersen vs sham
Acquisition of head control · infants with SMA and 2 SMN2 copies
Intrathecal injected nusinersen probably leads to higher acquisition of head control within one year after the onset of… compared with sham procedure (moderate certainty).
1 finding from 1 review
- RR 16.95 [1.04, 274.84]1 study · 110 participantsModerate
Intrathecal injected nusinersen vs sham
Acquisition of the ability to sit · infants with SMA and 2 SMN2 copies
Intrathecal injected nusinersen showed no clear difference in acquisition of the ability to sit within one year after the onset of… compared with sham procedure (moderate certainty).
1 finding from 1 review
- RR 6.68 [0.39, 115.38]1 study · 110 participantsModerate
Intrathecal injected nusinersen vs sham
Acquisition of the ability to stand · infants with SMA and 2 SMN2 copies
Intrathecal injected nusinersen showed no clear difference in acquisition of the ability to stand within one year after the onset… compared with sham procedure (moderate certainty).
1 finding from 1 review
- RR 1.54 [0.06, 36.92]1 study · 110 participantsModerate
Intrathecal injected nusinersen vs sham
Change in motor score after one year · infants with SMA and 2 SMN2 copies
Intrathecal injected nusinersen probably leads to higher change in motor disability score ‐ response on HINE‐2 within one… compared with sham procedure (moderate certainty).
1 finding from 1 review
- RR 38.51 [2.43, 610.14]1 study · 110 participantsModerate
Intrathecal injected nusinersen vs sham
Adverse events attributable to treatment · infants with SMA and 2 SMN2 copies
Intrathecal injected nusinersen showed no clear difference in adverse events attributable to treatment Measured as adverse events… compared with sham procedure (moderate certainty).
1 finding from 1 review
- RR 0.99 [0.92, 1.05]1 study · 121 participantsModerate
Intrathecal injected nusinersen vs sham
Severe adverse events attributable to treatment Measured as severe adverse events (all) · infants with SMA and 2 SMN2 copies
Intrathecal injected nusinersen probably leads to lower severe adverse events attributable to treatment Measured as severe… compared with sham procedure (moderate certainty).
1 finding from 1 review
- RR 0.7 [0.55, 0.89]1 study · 121 participantsModerate
Intervention not reported
Treatment failure · antiretroviral‐naïve individuals
The intervention showed no clear difference in treatment failure (low certainty).
1 finding from 1 review
- Efavirenz or nevirapine in three‐drug combination therapy with two nucleoside or nucleotide‐reverse transcriptase… 2016 · Cochrane Headline outcomes onlyRR 0.97 [0.76, 1.24]5 studies · 737 participantsLow
Intervention not reported
Retention at treatment completion (Any psychosocial intervention vs. control)
The intervention showed no clear difference in retention at treatment completion (Any psychosocial intervention vs.… (low certainty).
1 finding from 1 review
- Psychosocial interventions for pregnant women in outpatient illicit drug treatment programs compared to other… 2015 · Cochrane Headline outcomes onlyRR 0.99 [0.93, 1.06]9 studies · 743 participantsLow
Intervention not reported
Short term treatment retention (Any psychosocial intervention vs. control)
The intervention showed no clear difference in short term treatment retention (Any psychosocial intervention vs.… (low certainty).
1 finding from 1 review
- Psychosocial interventions for pregnant women in outpatient illicit drug treatment programs compared to other… 2015 · Cochrane Headline outcomes onlyRR 1 [0.9, 1.1]6 studies · 514 participantsLow
Intervention not reported
Retention at treatment completion (CM vs. control)
The intervention showed no clear difference in retention at treatment completion (CM vs. control) (low certainty).
1 finding from 1 review
- Psychosocial interventions for pregnant women in outpatient illicit drug treatment programs compared to other… 2015 · Cochrane Headline outcomes onlyRR 1.03 [0.92, 1.16]6 studies · 388 participantsLow
Intervention not reported
Retention at treatment completion (MIB interventions vs. control)
The intervention showed no clear difference in retention at treatment completion (MIB interventions vs. control) (low certainty).
1 finding from 1 review
- Psychosocial interventions for pregnant women in outpatient illicit drug treatment programs compared to other… 2015 · Cochrane Headline outcomes onlyRR 0.97 [0.89, 1.06]3 studies · 355 participantsLow
Intervention not reported
Proportion of patients who discontinued treatment due to adverse events (28 weeks trial period) · Patients between five and 15 years old with a diagnosis of BECTS
The intervention showed no clear difference in proportion of patients who discontinued treatment due to adverse… (low certainty).
1 finding from 1 review
- Comparison of antiepileptic drugs, no treatment, or placebo for children with benign epilepsy with centro temporal… 2014 · Cochrane Headline outcomes onlyRR 1.12 [0.36, 3.45]1 study · 112 participantsLow
Intervention not reported
Proportion of patients who discontinued treatment due to adverse events (over 6 months trial period) · Patients between three and 10 years old with a diagnosis of BECTS
1 finding from 1 review
- Comparison of antiepileptic drugs, no treatment, or placebo for children with benign epilepsy with centro temporal… 2014 · Cochrane Headline outcomes onlyno estimate extracted1 study · 66 participantsGRADE not reported
Intervention not reported
Proportion of patients who discontinued treatment due to adverse events (96 weeks trial period) · Patients with a clinical and EEG diagnosis of BECTS
It is very uncertain whether the intervention changes proportion of patients who discontinued treatment due to adverse… (very low certainty).
1 finding from 1 review
- Comparison of antiepileptic drugs, no treatment, or placebo for children with benign epilepsy with centro temporal… 2014 · Cochrane Headline outcomes onlyRR 0.72 [0.05, 10.76]1 study · 43 participantsVery low
Intervention not reported
Proportion of patients who discontinued treatment due to adverse events ( · Patients between three and 12 years old with clinical and EEG diagnosis of BECTS
The intervention showed no clear difference in proportion of patients who discontinued treatment due to adverse… (low certainty).
1 finding from 1 review
- Comparison of antiepileptic drugs, no treatment, or placebo for children with benign epilepsy with centro temporal… 2014 · Cochrane Headline outcomes onlyRR 0.86 [0.06, 12.75]1 study · 39 participantsLow
TDF vs AZT
Drug resistance · patients with initial ART
It is very uncertain whether TDF changes drug resistance compared with AZT (very low certainty).
1 finding from 1 review
- Tenofovir or zidovudine in three‐drug combination therapy with one nucleoside reverse transcriptase inhibitor and one… 2010 · Cochrane Headline outcomes onlyRR 20.43 [1.24, 335.9]1 study · 71 participantsVery low
Intervention not reported
All‐cause mortality at 2 days ‐ immediate treatment · patients with acute myocardial infarction1
The intervention leads to lower all‐cause mortality at 2 days ‐ immediate treatment (high certainty).
1 finding from 1 review
- Effect of early treatment with anti‐hypertensive drugs on short and long‐term mortality in patients with an acute… 2009 · Cochrane Headline outcomes onlyRR 0.81 [0.74, 0.89]6 studies · 82624 participantsHigh
Intervention not reported
All‐cause mortality at 10 days‐ short‐term treatment · patients with acute myocardial infarction1
The intervention leads to lower all‐cause mortality at 10 days‐ short‐term treatment (high certainty).
1 finding from 1 review
- Effect of early treatment with anti‐hypertensive drugs on short and long‐term mortality in patients with an acute… 2009 · Cochrane Headline outcomes onlyRR 0.91 [0.86, 0.97]6 studies · 78178 participantsHigh
Intervention not reported
All‐cause mortality at 2 days ‐ immediate treatment · acute myocardial infarction1
The intervention showed no clear difference in all‐cause mortality at 2 days ‐ immediate treatment (high certainty).
1 finding from 1 review
- Effect of early treatment with anti‐hypertensive drugs on short and long‐term mortality in patients with an acute… 2009 · Cochrane Headline outcomes onlyRR 0.91 [0.82, 1]3 studies · 77414 participantsHigh