Cochrane · systematic review · CD006779
Comparison of antiepileptic drugs, no treatment, or placebo for children with benign epilepsy with centro temporal spikes
Tan, HJ, Singh, J, Gupta, R, et al. · Cochrane Database of Systematic Reviews · 2014 · Cochrane Library
EpilepsyAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
22
current version
GRADE rated
18
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 4 · 18.2%Very low 8 · 36.4%Low 6 · 27.3%Moderate 4 · 18.2%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Comparison
Population: Patients with a clinical and EEG diagnosis of BECTS
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Proportion of patients who are seizure free between 4‐40 weeks | RR 1.04 | 1 study · 432 participants | Very low Downgraded: risk of bias, inconsistency |
Proportion of patients who had seizure remission in the last 9 months of the study | RR 1.06 | 1 study · 43 participants | Very low Downgraded: risk of bias, inconsistency |
Proportion of patients who discontinued treatment due to adverse events (96 weeks trial period) | RR 0.72 [0.05, 10.76] | 1 study · 43 participants | Very low Downgraded: risk of bias, inconsistency |
Proportion of patients who reported adverse events | RR 1.92 | 1 study · 43 participants | Very low Downgraded: risk of bias, inconsistency |
Proportion of patients with a particular or serious adverse event: 1. Vertigo 2. Headache 3. Somnolence 4. Nausea/Vomiting 5. Tremor 6. Fatigue | no estimate extracted | 1 study · 43 participants | Very low Downgraded: risk of bias, inconsistency |
Changes in cognitive function testing from baseline (96 weeks trial period) | no estimate extracted | 39 participants | Very low Downgraded: risk of bias, inconsistency |
Comparison
Population: Patients between three and 12 years old with clinical and EEG diagnosis of BECTS
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Proportion of patients who are seizure free at 3 months | RR 1.13 [0.93, 1.36] | 1 study · 39 participants | Very low Downgraded: imprecision, inconsistency |
Proportion of patients who are seizure free at 12 months | RR 1.29 [0.89, 1.86] | 1 study · 39 participants | Very low Downgraded: imprecision, inconsistency |
Proportion of patients who discontinued treatment due to adverse events ( | RR 0.86 [0.06, 12.75] | 1 study · 39 participants | Low Downgraded: imprecision, inconsistency |
Proportion of patients with an adverse event | RR 0.78 [0.15, 4.15] | 1 study · 39 participants | Low Downgraded: imprecision, inconsistency |
Changes in cognitive function | no estimate extracted | 1 study · 39 participants | Ungraded |
Comparison
Population: Patients between five and 15 years old with a diagnosis of BECTS
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Proportion of patients who are seizure free at 28 weeks | RR 0.98 [0.77, 1.25] | 1 study · 112 participants | Low Downgraded: risk of bias, imprecision |
Proportion of patients who discontinued treatment due to adverse events (28 weeks trial period) | RR 1.12 [0.36, 3.45] | 1 study · 112 participants | Low Downgraded: risk of bias, imprecision |
Proportion of patients with an adverse event: | no estimate extracted | 1 study · 112 participants | Ungraded |
Proportion of patients with a particular or serious adverse event: 1. Somnolence 2. Rash | no estimate extracted | 1 study · 112 participants | Low Downgraded: risk of bias, imprecision |
Changes in cognitive function testing from baseline (28 weeks trial period) | no estimate extracted | 1 study · 88 participants | Low Downgraded: risk of bias, imprecision |
Comparison
Population: Patients between three and 10 years old with a diagnosis of BECTS
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Proportion of patients who are seizure free at 3 months | RR 2.26 [1.48, 3.44] | 1 study · 66 participants | Moderate Downgraded: risk of bias, imprecision |
Proportion of patients who are seizure free at 6 months | RR 2.63 [1.43, 4.86] | 1 study · 66 participants | Moderate Downgraded: risk of bias, imprecision |
Time to first seizure after randomisation | Hazard ratio 7.8 [2.66, 22.87] | 1 study · 66 participants | Moderate Downgraded: risk of bias, imprecision |
Proportion of patients who discontinued treatment due to adverse events (over 6 months trial period) | no estimate extracted | 1 study · 66 participants | Ungraded |
Proportion of patients with an adverse event | RR 1.35 [0.83, 2.2] | 1 study · 66 participants | Moderate Downgraded: risk of bias, imprecision |
Changes in cognitive function | no estimate extracted | 1 study · 66 participants | Ungraded |