Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,018 questions · 3,100 findings · 369 reviews · Headline outcomes only

No studies found 774 · 25%GRADE not reported 108 · 3.5%Very low 727 · 23.5%Low 840 · 27.1%Moderate 474 · 15.3%High 177 · 5.7%

Summary of findings: cycled vs culture‐based antibiotic therapy

Time to next isolation of PA · children (aged 1 to 12 years) with CF and a newly isolated PA infection

Summary of findings: cycled probably leads to higher time to next isolation of PA compared with culture‐based antibiotic therapy (moderate certainty).

1 finding from 1 review

Summary of findings: cycled vs culture‐based antibiotic therapy

Adverse events: severe adverse events (total) · children (aged 1 to 12 years) with CF and a newly isolated PA infection

Summary of findings: cycled showed no clear difference in adverse events: severe adverse events (total) compared with culture‐based antibiotic therapy (moderate certainty).

1 finding from 1 review

Summary of findings: cycled vs culture‐based antibiotic therapy

Emergence of novel bacteria: isolation of novel gram negative organisms · children (aged 1 to 12 years) with CF and a newly isolated PA infection

Summary of findings: cycled showed no clear difference in emergence of novel bacteria: isolation of novel gram negative… compared with culture‐based antibiotic therapy (moderate certainty).

1 finding from 1 review

Single‐dose intravesical chemotherapy instillation vs placebo or observation after nephroureterectomy

Time to bladder cancer recurrence (absolute effect size estimates based on recurrence rate at 12 months)

Single‐dose intravesical chemotherapy instillation may leads to lower time to bladder cancer recurrence (absolute effect size estimates… compared with placebo or observation after nephroureterectomy (low certainty).

1 finding from 1 review

Impact of extended vs standard lymph node dissection on overall survival among patients with urothelial cancer of the bladder

Overall survival (absolute effect size estimates based on survival rate at 24 months) · Partcipants with bladder cancer undergoing radical cystectomy (male n = 314, female n = 87; age (interquartile range) 59 to 74)Country:…

Impact of extended showed no clear difference in time to death from any cause (absolute effect size estimates based… compared with standard lymph node dissection on overall survival among patients… (low certainty).

1 finding from 1 review

Impact of extended vs standard lymph node dissection on overall survival among patients with urothelial cancer of the bladder

Time to death from bladder cancer · Partcipants with bladder cancer undergoing radical cystectomy (male n = 314, female n = 87; age (interquartile range) 59 to 74)Country:…

Impact of extended showed no clear difference in time to death from bladder cancer (absolute effect size estimates… compared with standard lymph node dissection on overall survival among patients… (low certainty).

1 finding from 1 review

Impact of extended vs standard lymph node dissection on overall survival among patients with urothelial cancer of the bladder

Clavien‐Dindo grade ≥ 3 complications · Partcipants with bladder cancer undergoing radical cystectomy (male n = 314, female n = 87; age (interquartile range) 59 to 74)Country:…

It is very uncertain whether impact of extended changes clavien‐Dindo grade ≥ 3 complications compared with standard lymph node dissection on overall survival among patients… (very low certainty).

1 finding from 1 review

Impact of extended vs standard lymph node dissection on overall survival among patients with urothelial cancer of the bladder

Time to recurrence · Partcipants with bladder cancer undergoing radical cystectomy (male n = 314, female n = 87; age (interquartile range) 59 to 74)Country:…

It is very uncertain whether impact of extended changes time to recurrence (absolute effect size estimates based on… compared with standard lymph node dissection on overall survival among patients… (very low certainty).

1 finding from 1 review