Cochrane · systematic review · CD013336
Extended versus standard lymph node dissection for urothelial carcinoma of the bladder in patients undergoing radical cystectomy
Hwang, EC, Sathianathen, NJ, Imamura, M, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
UrologyAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
5
No studies
1
Included studies
NR
No studies 1 · 16.7%Ungraded 0 · 0%Very low 3 · 50%Low 2 · 33.3%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Impact of extended versus standard lymph node dissection on overall survival among patients with urothelial cancer of the bladder
Population: Partcipants with bladder cancer undergoing radical cystectomy (male n = 314, female n = 87; age (interquartile range) 59 to 74)Country: Germany
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Time to death from any cause (absolute effect size estimates based on death rate at 5 years) Impact of extended vs standard lymph node dissection on overall survival among patients with urothelial cancer of the bladder | HR 0.78 [0.57, 1.07] | 1 study · 401 participants | Low Downgraded: risk of bias |
Time to death from bladder cancer (absolute effect size estimates based on death rate at 5 years) Impact of extended vs standard lymph node dissection on overall survival among patients with urothelial cancer of the bladder | HR 0.7 [0.45, 1.07] | 1 study · 401 participants | Low Downgraded: risk of bias |
Clavien‐Dindo grade ≥ 3 complications Impact of extended vs standard lymph node dissection on overall survival among patients with urothelial cancer of the bladder | RR 1.13 [0.84, 1.52] | 1 study · 401 participants | Very low Downgraded: risk of bias |
Time to recurrence (absolute effect size estimates based on recurrence rate at 5 years) Impact of extended vs standard lymph node dissection on overall survival among patients with urothelial cancer of the bladder | HR 0.84 [0.58, 1.22] | 1 study · 401 participants | Very low Downgraded: risk of bias |
Clavien‐Dindo grade ≤ 2 complications8 Impact of extended vs standard lymph node dissection on overall survival among patients with urothelial cancer of the bladder | RR 0.94 [0.74, 1.19] | 1 study · 401 participants | Very low Downgraded: risk of bias |
Disease‐specific quality of life9 Impact of extended vs standard lymph node dissection on overall survival among patients with urothelial cancer of the bladder | no estimate extracted | NR | No studies |