Bacterial collagenolytic protease gene expression · Human ex vivo carious lesions / caries-associated biofilm
Genes encoding bacterial collagenolytic proteases were detected/overexpressed in coronal and root caries (ungraded; GRADE not feasible).
1 finding from 1 review
Genes coding for bacterial collagenolytic proteases were significantly expressed/overrepresented in coronal (Simon-Soro et al., 2013) and root (Dame-Teixeira et al., 2018: 42 proteases differentially expressed, 18…
2 studies · 25 participants
GRADE not reported
MMP-2 expression/activity · Human carious dentin from irradiated and non-irradiated subjects
No difference in MMP-2 activity or expression was reported between irradiated and non-irradiated carious dentin.
1 finding from 1 review
MMP-8 expression/activity · Human ex vivo carious dentin under sealed cavities
MMP-8 may be higher before than after cavity sealing, but the evidence is very uncertain (very low certainty).
1 finding from 1 review
MMP-9 expression/activity · Human ex vivo carious dentin (head/neck radiotherapy)
MMP-9 showed no increase in irradiated vs non-irradiated carious dentin (one study; ungraded).
1 finding from 1 review
MMP-9 expression/activity · Human ex vivo carious dentin under sealed cavities
MMP-9 shows no difference before vs after cavity sealing; the evidence is very uncertain (very low certainty).
1 finding from 1 review
MMP-2 expression/activity · Human carious dentin
No difference in MMP-2 expression/activity was found before versus after cavity sealing (very low certainty).
1 finding from 1 review
MMP-13 presence/activity · Human ex vivo carious dentin
MMP-13 may be increased in root compared with coronal carious dentin, but the evidence is very uncertain (very low certainty).
1 finding from 1 review
Cathepsin B (CT-B) presence/activity · Human ex vivo carious dentin (mostly coronal), natural caries lesions
Cathepsin B may be increased in carious dentin compared with sound dentin, but the evidence is very uncertain (very low certainty).
1 finding from 1 review
CT-B may be increased in carious dentin when compared to sound dentin, but the evidence is very uncertain (Vidal et al., 2014; Nascimento et al., 2011: significantly higher in caries, p<0.05).
2 studies · 22 participants
Very low
MMP-8 location/presence · Human carious dentin
Evidence on MMP-8 by lesion depth or location was very low certainty.
1 finding from 1 review
MMP-20 expression · Human carious dentin from irradiated and non-irradiated subjects
No difference in MMP-20 expression was found between irradiated and non-irradiated carious dentin (very low certainty).
1 finding from 1 review
MMP-2 expression/activity · Human ex vivo carious dentin under sealed cavities
MMP-2 shows no difference before vs after cavity sealing; the evidence is very uncertain (very low certainty).
1 finding from 1 review
MMP-20 expression · Human ex vivo carious dentin (head/neck radiotherapy)
MMP-20 shows no difference between irradiated and non-irradiated carious dentin; the evidence is very uncertain (very low certainty).
1 finding from 1 review
There is no difference about the MMP-20 expression in irradiated vs. non-irradiated carious dentin, but the evidence is very uncertain (Gomes-Silva et al., 2017b).
1 study · 36 participants
Very low
Cathepsin B (CT-B) presence/activity · Human coronal carious dentin and sound dentin
Cathepsin B may be increased in carious dentin compared with sound dentin (very low certainty).
1 finding from 1 review
MMP-20 expression · Human carious dentin
MMP-20 probably reduces in outer compared with inner carious dentin (moderate certainty).
1 finding from 1 review
no estimate extracted
1 study · 5 participants
Moderate
Differential microbial abundance / taxa predictive of caries · Individuals providing oral (saliva/supragingival plaque) 16S rRNA microbiome samples; 2016 samples from 19 studies (mixed children and…
A group of genera/species (notably Selenomonas, Aggregatibacter, Actinomyces, Treponema) was predictive of caries, whereas Streptococcus was not (ungraded).
1 finding from 1 review
Meta-analysis of caries microbiome studies can improve upon disease prediction outcomes. 2022 All outcomesOral cavity microbiome (saliva and supragingival plaque samples); pooled across 19 international studies
Mean-decrease-accuracy discriminating taxa: Capnocytophaga HMT-338, Lactobacillus panis, Treponema HMT-230, Bifidobacterium longum, Delftia acidovorans, Staphylococcus schleiferi; higher log2FC in caries: Selenomonas HMT-146, Aggregatibacter actinomycetemcomitans, Actinomyces HMT-896, Treponema HMT-257; Streptococcus not predictive
19 studies · 2016 participants
GRADE not reported
Dental caries prevalence · Children aged 12 years (plus or minus one year) in Africa
The pooled dental-caries prevalence was 0.3657 (95% CI 0.3065 to 0.4250); GRADE was not reported.
2 findings from 1 review
Prevalence 0.3657 [0.3065, 0.4250]
Studies not reported
GRADE not reported
Prevalence 0.356 [0.294, 0.417]
Studies not reported
GRADE not reported
Intervention not reported
Caries prevalence
1 finding from 1 review
Intervention not reported
Dental caries prevalence
1 finding from 1 review
Intervention not reported
Dental caries prevalence · General population (children and adults) in East Africa
Caries prevalence in permanent dentition (>=12 years) was 50.2% (95% CI 38.4 to 62.1); certainty not graded.
1 finding from 1 review
Intervention not reported
Dental caries prevalence · General population (children and adults) in East Africa
The pooled prevalence of dental caries in East Africa (2000-2020) was 45.7% (95% CI 38.0 to 53.4); certainty not graded.
1 finding from 1 review