Question · asked by 1 review
Carious dentin before cavity sealing vs Carious dentin after cavity sealing: MMP-8 expression/activity
- Population
- Human ex vivo carious dentin under sealed cavities
- Intervention
- Carious dentin before cavity sealing
- Comparison
- Carious dentin after cavity sealing
- Outcome
- MMP-8 expression/activity
MMP-8 may be higher before than after cavity sealing, but the evidence is very uncertain (very low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Carious dentin before cavity sealing vs Carious dentin after cavity sealing MMP-8 expression/activity · Human ex vivo carious dentin under sealed cavities · Before vs after sealing (Kuhn 2016: 60 days follow-up), Ex vivo (extracted teeth / clinical carious or biofilm samples) MMP-8 may be higher before than after cavity sealing, but the evidence is very uncertain (very low certainty). Presence of host and bacterial-derived collagenolytic proteases in carious dentin: a systematic review of ex… (2023) All outcomes | MMP-8 may be increased in the dentin before when compared to dentin after cavity sealing; MMP-8 significantly reduced after 60 days of sealing (Kuhn et al., 2016; Chibinski et al., 2014). | 2 studies · 48 participants | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Presence of host and bacterial-derived collagenolytic proteases in carious dentin: a systematic review of ex vivo studies. 2023 All outcomes | March 2022 | 18 | Not applicable |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.