Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

764 questions · 795 findings · 110 reviews

No studies found 202 · 25.4%GRADE not reported 100 · 12.6%Very low 225 · 28.3%Low 155 · 19.5%Moderate 85 · 10.7%High 28 · 3.5%

Acetazolamide vs placebo

Incidence of high altitude cerebral oedema (HACE) ‐ not reported · participants at risk of high altitude illness

Acetazolamide showed no clear difference in incidence of high altitude cerebral oedema (HACE)‐ Follow‐ up: From… compared with placebo (moderate certainty).

1 finding from 1 review

Acetazolamide vs placebo

Adverse events: Paresthesias‐ Follow‐ up: From arrival to 24 hours later · participants at risk of high altitude illness

Acetazolamide may leads to higher adverse events: Paresthesias‐ Follow‐ up: From arrival to 24 hours… compared with placebo (low certainty).

1 finding from 1 review

Budesonide vs placebo

Incidence of acute mountain sickness (AMS)‐ Follow‐ up: From arrival to 24 hours later · participants at risk of high altitude illness

Budesonide may leads to lower incidence of acute mountain sickness (AMS)‐ Follow‐ up: From arrival… compared with placebo (low certainty).

1 finding from 1 review

Insulin vs anti‐diabetic agent

Perinatal (fetal and neonatal death) and later infant mortality · Infants of women diagnosed with gestational diabetes

Insulin showed no clear difference in perinatal (fetal and neonatal death) and later infant mortality compared with anti‐diabetic agent (low certainty).

1 finding from 1 review

Lidocaine vs propafenone

Adverse events (AEs; adverse drug reaction): bilateral bundle branch block · patients with myocardial infarction

It is very uncertain whether lidocaine changes adverse events (AEs; adverse drug reaction): bilateral bundle branch… compared with propafenone (very low certainty).

1 finding from 1 review

Summary of findings: split‐spinous process laminotomy vs conventional laminectomy

VAS back (0 to 10) Unilateral laminotomy compared with conventional laminectomy · patients with lumbar stenosis

It is very uncertain whether summary of findings: split‐spinous process laminotomy changes VAS back (0 to 10) Unilateral laminotomy compared with conventional… compared with conventional laminectomy (very low certainty).

1 finding from 1 review

Repelling-magnet splints vs Bite-blocks

Side effects / adverse effects (unilateral crossbite; transverse problems) · Children and adolescents (over 80% aged 16 years or younger at treatment start) with anterior open bite (lack of vertical overlap or…
1 finding from 1 review
  • Orthodontic and orthopaedic treatment for anterior open bite in children 2014 · Cochrane All outcomes
    About 4 months (treatment interrupted early)
    "After 4 months the open bite was observed to close in the magnet group, but in four out of these ten patients, transverse problems were observed (unilateral crossbite) which led to the interruption of the treatment…
    1 study · 10 participants
    GRADE not reported

Intra-articular injection of sodium hyaluronate vs corticosteroid injection

Pain on palpation of the affected/contralateral TMJ and masticatory muscles · Adults (>18 years) with temporomandibular joint osteoarthritis (TMJ OA) diagnosed by RDC/TMD or compatible criteria

Intra-articular injection of sodium hyaluronate led to lower pain on palpation of the affected/contralateral TMJ and masticatory… compared with intra-articular injection of corticosteroids (betamethasone); GRADE not reported.

1 finding from 1 review
  • Interventions for managing temporomandibular joint osteoarthritis 2012 · Cochrane All outcomes
    14 days to 6 months
    Pain on palpation of the affected and contralateral TMJ and masticatory muscles presented similar frequencies regardless of the time (Analyses 1.4-1.12); no statistically significant differences reported. Point…
    1 study · 40 participants
    GRADE not reported

Intra-articular injection of sodium hyaluronate vs corticosteroid injection

Extent of mandibular movement (maximum jaw opening, lateral and contralateral movement, jaw protrusion) · Adults (>18 years) with temporomandibular joint osteoarthritis (TMJ OA) diagnosed by RDC/TMD or compatible criteria

Intra-articular injection of sodium hyaluronate showed no clear difference in extent of mandibular movement (maximum jaw opening, lateral and… compared with intra-articular injection of corticosteroids (betamethasone); GRADE not reported.

1 finding from 1 review
  • Interventions for managing temporomandibular joint osteoarthritis 2012 · Cochrane All outcomes
    14 days to 6 months
    None of the mean differences between interventions for the measures of jaw movements (maximum jaw opening, lateral movement to affected side, contralateral movement, jaw protrusion; Analyses 1.16-1.27) showed…
    1 study · 40 participants
    GRADE not reported