Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

535 questions · 545 findings · 129 reviews · Headline outcomes only

No studies found 131 · 24%GRADE not reported 30 · 5.5%Very low 123 · 22.6%Low 136 · 25%Moderate 98 · 18%High 27 · 5%

Bexarotene + PUVA vs PUVA

Common adverse effects ‐ Photosensitivity (Time point of measurement: up to 16 weeks) · people with mycosis fungoides

Bexarotene + PUVA showed no clear difference in common adverse effects ‐ Photosensitivity (Time point of… compared with PUVA alone (low certainty).

1 finding from 1 review

Bexarotene + PUVA vs PUVA

Objective response rate · people with mycosis fungoides

Bexarotene + PUVA showed no clear difference in objective response rate (Time point of measurement: up to 16 weeks) compared with PUVA alone (low certainty).

1 finding from 1 review

Laxative plus bulking agent vs laxative alone

Adverse effects on women: faecal incontinence during first 10 postpartum days · postpartum women who underwent surgical repair of third degree perineal tears

It is very uncertain whether laxative plus bulking agent changes adverse effects on women: faecal incontinence during first 10… compared with laxative alone (very low certainty).

1 finding from 1 review

Topical antibiotics with steroids vs topical antibiotics

Suspected ototoxicity: dizziness/vertigo/balance · people (of any age) with chronic suppurative otitis media or ear discharge

It is very uncertain whether topical antibiotics with steroids changes suspected ototoxicity: dizziness/vertigo/balance compared with topical antibiotics alone (very low certainty).

1 finding from 1 review

PPI plus usual care vs usual care alone or chronic obstructive pulmonary disease

Acute respiratory infections study duration: 12 months · patients with chronic obstructive pulmonary disease

It is very uncertain whether PPI plus usual care changes acute respiratory infections study duration: 12 months compared with usual care alone or chronic obstructive pulmonary disease (very low certainty).

1 finding from 1 review

GnRH agonist plus chemotherapy vs chemotherapy alone

Adverse effects: hot flush · premenopausal women with malignant conditions, receiving GnRH agonist before or in parallel to chemotherapy

It is very uncertain whether gnRH agonist plus chemotherapy changes adverse effects: hot flush compared with chemotherapy alone (very low certainty).

1 finding from 1 review

GnRH agonist plus chemotherapy vs chemotherapy alone

Adverse effects: vaginal dryness · premenopausal women with malignant conditions, receiving GnRH agonist before or in parallel to chemotherapy

GnRH agonist plus chemotherapy showed no clear difference in adverse effects: vaginal dryness compared with chemotherapy alone (moderate certainty).

1 finding from 1 review