Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,615 questions · 1,673 findings · 190 reviews · Headline outcomes only

No studies found 278 · 16.6%GRADE not reported 85 · 5.1%Very low 328 · 19.6%Low 460 · 27.5%Moderate 402 · 24%High 120 · 7.2%

Dual therapy (angiotensin‐converting‐enzyme inhibitors plus angiotensin receptor blockers) vs placebo or no treatment

Fatal or nonfatal myocardial infarction · people with diabetes and kidney disease

The review found no eligible studies for this question.

1 finding from 1 review

Dual therapy (angiotensin‐converting‐enzyme inhibitors plus angiotensin receptor blockers) vs placebo or no treatment

Micro‐ to normoalbuminuria6 · people with diabetes and kidney disease

It is very uncertain whether dual therapy (angiotensin‐converting‐enzyme inhibitors plus… changes micro‐ to normoalbuminuria6 compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Systems training for emotional predictability and problem solving for borderline personality disorder + individual therapy (STEPPS+IT) vs treatment

Impulsivity · patients with borderline personality disorder

Systems training for emotional predictability and problem solving… showed no clear difference in impulsivityno. of participants scoring above BPDSI‐IV3 impulsivity… compared with treatment (low certainty).

1 finding from 1 review

Systems training for emotional predictability and problem solving for borderline personality disorder + individual therapy (STEPPS+IT) vs treatment

Parasuicidalityno. of participants scoring above BPDSI‐IV3 parasuicide cut‐off score · patients with borderline personality disorder

Systems training for emotional predictability and problem solving… showed no clear difference in parasuicidalityno. of participants scoring above BPDSI‐IV3… compared with treatment (low certainty).

1 finding from 1 review

Intervention not reported

Renal failure (number of individuals with an elevation of serum creatinine greater than 2 mg/dL or requiring dialysis)

The intervention showed no clear difference in renal failure (number of individuals with an elevation of serum… (low certainty).

1 finding from 1 review

Summary of findings table ‐ Mental Health First Aid (MHFA) training vs control

Mental health outcomes · improving mental health and wellbeing

It is very uncertain whether summary of findings table ‐ Mental Health First Aid (MHFA) training changes individual mental health compared with control (very low certainty).

1 finding from 1 review