Cochrane · systematic review · CD002011
Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis
Main, E, Rand, S · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library
Cystic Fibrosis and Genetic DisordersAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
42
current version
GRADE rated
26
No studies
16
Included studies
NR
No studies 16 · 38.1%Ungraded 0 · 0%Very low 26 · 61.9%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
CCPT versus PEP
Population: children and adults with cystic fibrosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
FEV1: change from baseline in FEV1 % predicted CCPT vs PEP | no estimate extracted | 6 studies · 169 participants | Very low Downgraded: risk of bias, imprecision |
FVC: change from baseline in FVC % predicted CCPT vs PEP | no estimate extracted | 6 studies · 169 participants | Very low Downgraded: risk of bias, imprecision |
FEF25–75: change from baseline in FEF25–75 CCPT vs PEP | no estimate extracted | 4 studies · 87 participants | Very low Downgraded: risk of bias, imprecision |
Respiratory exacerbations: number of respiratory exacerbations per year CCPT vs PEP | no estimate extracted | NR | No studies |
QoL: change in QWB CCPT vs PEP | no estimate extracted | 1 study · 66 participants | Very low Downgraded: risk of bias, imprecision |
Adherence to therapy and individual preference CCPT vs PEP | no estimate extracted | 8 studies · 224 participants | Very low Downgraded: risk of bias, imprecision |
Mucus weight CCPT vs PEP | no estimate extracted | 4 studies · 75 participants | Very low Downgraded: risk of bias, imprecision |
CCPT versus extrapulmonary mechanical percussion
Population: children and adults with cystic fibrosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
FEV1: rate of decline in FEV1 % predicted CCPT vs extrapulmonary mechanical percussion | no estimate extracted | 1 study · 151 participants | Very low Downgraded: risk of bias, imprecision |
FVC: rate of decline in FVC % predicted. CCPT vs extrapulmonary mechanical percussion | no estimate extracted | 1 study · 151 participants | Very low Downgraded: risk of bias, imprecision |
FEF25–75: rate of decline in FEF25–75 CCPT vs extrapulmonary mechanical percussion | no estimate extracted | 1 study · 151 participants | Very low Downgraded: risk of bias, imprecision |
Respiratory exacerbations: time to first treatment with IV antibiotics CCPT vs extrapulmonary mechanical percussion | no estimate extracted | 1 study · 151 participants | Very low Downgraded: risk of bias, imprecision |
QoL: change in CFQ score CCPT vs extrapulmonary mechanical percussion | no estimate extracted | 1 study · 151 participants | Very low Downgraded: risk of bias, imprecision |
Adherence to therapy and individual preference (change in adherence rate and TSS score) CCPT vs extrapulmonary mechanical percussion | no estimate extracted | 1 study · 131 participants | Very low Downgraded: risk of bias, imprecision |
Mucus weight CCPT vs extrapulmonary mechanical percussion | no estimate extracted | NR | No studies |
CCPT versus ACBT
Population: children and adults with cystic fibrosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
FEV1: annual decline in FEV1 % predicted CCPT vs ACBT | MD 2.8 | 1 study · 63 participants | Very low Downgraded: risk of bias, imprecision |
FVC: annual decline in FVC % predicted CCPT vs ACBT | MD 1.8 | 1 study · 63 participants | Very low Downgraded: risk of bias, imprecision |
FEF25–75: annual decline in FEF25–75 % predicted CCPT vs ACBT | MD 6 [0.55, 11.45] | 1 study · 63 participants | Very low Downgraded: risk of bias, imprecision |
Respiratory exacerbations: time to first exacerbation CCPT vs ACBT | no estimate extracted | NR | No studies |
QoL: change in CFQ score CCPT vs ACBT | no estimate extracted | NR | No studies |
Adherence to therapy and individual preference: self‐reported scoring system. CCPT vs ACBT | no estimate extracted | NR | Very low Downgraded: risk of bias, imprecision |
Mucus weight CCPT vs ACBT | no estimate extracted | NR | No studies |
CCPT versus O‐PEP devices
Population: children and adults with cystic fibrosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
FEV1: % predicted at end of study CCPT vs O‐PEP devices | no estimate extracted | 3 studies · 185 participants | Very low Downgraded: risk of bias, imprecision |
FVC: % predicted at end of study CCPT vs O‐PEP devices | no estimate extracted | 3 studies · 185 participants | Very low Downgraded: risk of bias, imprecision |
FEF25–75: at end of the study CCPT vs O‐PEP devices | no estimate extracted | 2 studies · 171 participants | Very low Downgraded: risk of bias, imprecision |
Respiratory exacerbations: number of respiratory exacerbations per year CCPT vs O‐PEP devices | no estimate extracted | NR | No studies |
QoL: change in CFQ score (across 12 domains) CCPT vs O‐PEP devices | no estimate extracted | 1 study · 155 participants | Very low Downgraded: risk of bias, imprecision |
Adherence to therapy and individual preference: TSS score CCPT vs O‐PEP devices | no estimate extracted | 1 study · 155 participants | Very low Downgraded: risk of bias, imprecision |
Mucus weight CCPT vs O‐PEP devices | no estimate extracted | 1 study · 14 participants | Very low Downgraded: risk of bias, imprecision |
CCPT versus AD
Population: children and adolescents with cystic fibrosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
FEV1: % predicted CCPT vs AD | no estimate extracted | 2 studies · 54 participants | Very low Downgraded: risk of bias, imprecision |
FVC: % predicted CCPT vs AD | no estimate extracted | 2 studies · 54 participants | Very low Downgraded: risk of bias, imprecision |
FEF25–75: % predicted CCPT vs AD | no estimate extracted | 2 studies · 54 participants | Very low Downgraded: risk of bias, imprecision |
Respiratory exacerbations: number of respiratory exacerbations per year CCPT vs AD | no estimate extracted | NR | No studies |
QoL CCPT vs AD | no estimate extracted | NR | No studies |
Adherence to therapy and individual preference CCPT vs AD | no estimate extracted | 1 study · 36 participants | Very low Downgraded: risk of bias, imprecision |
Mucus weight CCPT vs AD | no estimate extracted | NR | No studies |
CCPT versus exercise
Population: children and young adults with cystic fibrosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
FEV1 CCPT vs exercise | no estimate extracted | NR | No studies |
FVC CCPT vs exercise | no estimate extracted | NR | No studies |
FEF25–75 CCPT vs exercise | no estimate extracted | NR | No studies |
Respiratory exacerbations: number of respiratory exacerbations per year CCPT vs exercise | no estimate extracted | NR | No studies |
QoL CCPT vs exercise | no estimate extracted | NR | No studies |
Adherence to therapy and individual preference CCPT vs exercise | no estimate extracted | NR | No studies |
Mucus weight CCPT vs exercise | no estimate extracted | NR | No studies |