Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

864 questions · 895 findings · 140 reviews · Headline outcomes only

No studies found 202 · 22.6%GRADE not reported 53 · 5.9%Very low 227 · 25.4%Low 254 · 28.4%Moderate 131 · 14.6%High 28 · 3.1%

Continuous positive airway pressure (CPAP) plus best supportive care vs best supportive care

All‐cause mortality ‐ after 24 months Number of participants: 287(2 RCTs)

It is very uncertain whether continuous positive airway pressure (CPAP) plus best supportive care changes all‐cause mortality ‐ after 24 months Number of participants: 287(2… compared with best supportive care (very low certainty).

1 finding from 1 review

Continuous positive airway pressure (CPAP) plus best supportive care vs best supportive care

Time to life‐saving cardiovascular intervention

Continuous positive airway pressure (CPAP) plus best supportive care may leads to lower time to life‐saving cardiovascular intervention ( compared with best supportive care (low certainty).

1 finding from 1 review

Oestrogen in combination with progestogen (sequential or continuous) vs placebo

Withdrawals due to adverse events · women with PMS

It is very uncertain whether oestrogen in combination with progestogen (sequential or continuous) changes withdrawal due to adverse events over 2 to 4 menstrual cycles1 compared with placebo (very low certainty).

1 finding from 1 review

Oestrogen in combination with progestogen (sequential or continuous) vs placebo

Specific adverse events · women with PMS

It is very uncertain whether oestrogen in combination with progestogen (sequential or continuous) changes specific adverse events over 2 to 4 menstrual cycles1 compared with placebo (very low certainty).

1 finding from 1 review

Summary of findings table – disulfiram vs placebo or no pharmacological treatment

Continuous abstinence from cocaine (number of participants who had achieved and maintained abstinence for at least three weeks at the end of treatment) · patients with the treatment of cocaine dependence

Summary of findings table – disulfiram showed no clear difference in continuous abstinence from cocaine (number of participants who had… compared with placebo or no pharmacological treatment (low certainty).

1 finding from 1 review

Psychosocial interventions vs treatment

Number of continuously abstinent women ‐ total · stopping or reducing alcohol consumption during pregnancy

Summary of findings table ‐ Any psychosocial intervention may leads to higher number of continuously abstinent women ‐ total compared with treatment (low certainty).

1 finding from 1 review