Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,432 questions · 1,467 findings · 116 reviews · Headline outcomes only

No studies found 232 · 15.8%GRADE not reported 202 · 13.8%Very low 286 · 19.5%Low 327 · 22.3%Moderate 286 · 19.5%High 134 · 9.1%

Taxane‐platinum‐fluoropyrimidine combinations vs taxane‐platinum (without fluoropyrimidine)

Progression‐free survival · people with advanced gastric cancer

Taxane‐platinum‐fluoropyrimidine combinations probably leads to lower progression‐free survival compared with taxane‐platinum (without fluoropyrimidine) (moderate certainty).

1 finding from 1 review

Taxane‐platinum‐fluoropyrimidine combinations vs taxane‐platinum (without fluoropyrimidine)

Treatment‐related death · people with advanced gastric cancer

It is very uncertain whether taxane‐platinum‐fluoropyrimidine combinations changes treatment‐related death compared with taxane‐platinum (without fluoropyrimidine) (very low certainty).

1 finding from 1 review

Taxane‐platinum‐fluoropyrimidine combinations vs taxane‐platinum (without fluoropyrimidine)

Treatment discontinuation due to toxicity · people with advanced gastric cancer

It is very uncertain whether taxane‐platinum‐fluoropyrimidine combinations changes treatment discontinuation due to toxicity compared with taxane‐platinum (without fluoropyrimidine) (very low certainty).

1 finding from 1 review

Tenofovir‐based antiviral combination regimens vs placebo or tenofovir alone or non‐tenofovir‐based antiviral regimens

All‐cause infant mortality at longest · HIV‐positive pregnant women co‐infected with hepatitis B virus

It is very uncertain whether tenofovir‐based antiviral combination regimens changes all‐cause infant mortality at longest compared with placebo or tenofovir alone or non‐tenofovir‐based antiviral regimens (very low certainty).

1 finding from 1 review

Tenofovir‐based antiviral combination regimens vs placebo or tenofovir alone or non‐tenofovir‐based antiviral regimens

Proportion of infants with serious adverse events ( · HIV‐positive pregnant women co‐infected with hepatitis B virus

It is very uncertain whether tenofovir‐based antiviral combination regimens changes proportion of infants with serious adverse events ( compared with placebo or tenofovir alone or non‐tenofovir‐based antiviral regimens (very low certainty).

1 finding from 1 review

Tenofovir‐based antiviral combination regimens vs placebo or tenofovir alone or non‐tenofovir‐based antiviral regimens

Proportion of infants with HBV mother‐to‐child transmission · HIV‐positive pregnant women co‐infected with hepatitis B virus
1 finding from 1 review

Tenofovir‐based antiviral combination regimens vs placebo or tenofovir alone or non‐tenofovir‐based antiviral regimens

Proportion of mothers with serious adverse events ( · HIV‐positive pregnant women co‐infected with hepatitis B virus

It is very uncertain whether tenofovir‐based antiviral combination regimens changes proportion of mothers with serious adverse events ( compared with placebo or tenofovir alone or non‐tenofovir‐based antiviral regimens (very low certainty).

1 finding from 1 review

IStent in combination with phacoemulsification vs phacoemulsification alone

Proportion of participants who were drop‐free · open‐angle glaucoma

It is very uncertain whether IStent in combination with phacoemulsification changes proportion of participants who were drop‐free compared with phacoemulsification alone (very low certainty).

1 finding from 1 review

A combination of individual‐level interventions vs no intervention/wait list/placebo/no stress‐reduction intervention

Stress symptoms ( · healthcare workers
3 findings from 1 review

Combination of anticholinergics + beta2‐agonists vs B2‐agonists alone

Asthma clinical scores · children hospitalised with an acute asthma exacerbation

Combination of anticholinergics + beta2‐agonists showed no clear difference in asthma clinical scores compared with beta2‐agonists alone (moderate certainty).

1 finding from 1 review