Cochrane · systematic review · CD010283
Inhaled anticholinergics and short‐acting beta₂‐agonists versus short‐acting beta2‐agonists alone for children with acute asthma in hospital
Vézina, K, Chauhan, BF, Ducharme, FM · Cochrane Database of Systematic Reviews · 2014 · Cochrane Library
AirwaysAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 6 · 100%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Combination of anticholinergics + beta2‐agonists versus beta2‐agonists alone
Population: children hospitalised with an acute asthma exacerbation
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Duration of the hospital stay (hours) Combination of anticholinergics + beta2‐agonists vs beta2‐agonists alone | no estimate extracted | 3 studies · 327 participants | Moderate Downgraded: imprecision |
Time to regular dose of short‐acting beta2‐agonists (hours) Combination of anticholinergics + beta2‐agonists vs beta2‐agonists alone | no estimate extracted | 2 studies · 269 participants | Moderate Downgraded: imprecision |
Asthma clinical scores Combination of anticholinergics + beta2‐agonists vs beta2‐agonists alone | no estimate extracted | 2 studies · 117 participants | Moderate Downgraded: imprecision |
Admission to the intensive care unit Combination of anticholinergics + beta2‐agonists vs beta2‐agonists alone | no estimate extracted | 1 study · 210 participants | Moderate Downgraded: imprecision |
Overall withdrawals Combination of anticholinergics + beta2‐agonists vs beta2‐agonists alone | OR 0.59 [0.27, 1.3] | 2 studies · 294 participants | Moderate Downgraded: imprecision |
Adverse health events Combination of anticholinergics + beta2‐agonists vs beta2‐agonists alone | no estimate extracted | 2 studies · 290 participants | Moderate Downgraded: imprecision |