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Evidence found and GRADE certainty

2,745 questions · 4,389 findings · 203 reviews · Oral Health

No studies found 39 · 0.9%GRADE not reported 3,844 · 87.6%Very low 198 · 4.5%Low 137 · 3.1%Moderate 134 · 3.1%High 37 · 0.8%

Conventional restorative treatment with resin composite (CRT-RC) vs Sealing

Caries lesion arrestment · Children with dentin caries lesions in the outer half of dentin on occlusal surfaces of primary teeth

Resin sealing and conventional restorative treatment (resin composite) did not differ significantly for caries lesion arrestment in outer-half occlusal dentin caries of primary teeth (2 studies; low certainty).

1 finding from 1 review

Fluorides combined with CPP-ACP vs Fluorides alone (monotherapy)

Total lesion area divided by total surface area (visual) · Patients with early caries lesions in permanent teeth (non-fluoridated water area)

Adding CPP-ACP to fluorides did not significantly change the lesion-area outcome for smooth-surface early caries lesions versus fluorides alone; not GRADE-rated.

1 finding from 1 review

Placebo vs no treatment

Caries increment, surface index D(M)FS · Children or adolescents

In the illustrative network meta-regression the SMD for caries increment differed between placebo and no treatment at randomization years 1970 to 1990; certainty was not graded.

1 finding from 1 review

Fluoride in dentifrice vs no treatment

Caries increment in permanent teeth · Children or adolescents

The NMR reported a difference between fluoride in dentifrice and no treatment at every displayed randomisation year; no GRADE assessment was reported.

1 finding from 1 review

Fluoride gel (topically applied; operator- or self-applied; any fluoride agent/concentration; frequency at least once a year) vs placebo

Caries increment, surface index D(M)FS · Children or adolescents

In the illustrative network meta-regression the SMD for caries increment differed between fluoride in gel and placebo at randomization years 1954 to 1980; certainty was not graded.

1 finding from 1 review

Early extraction of a compromised first permanent molar vs Non-extraction (retained first permanent molar) or contralateral non-extraction side

Spontaneous space closure · Children aged 5 to 15 years with a compromised first permanent molar

Early extraction of a compromised first permanent molar is followed by variable spontaneous closure of the post-extraction space (about 45.5% to 85.2% of cases); certainty was not GRADE-rated (Shekelle category III).

1 finding from 1 review

Fluoride varnish vs Fluoride in rinse

Caries increment, surface index D(M)FS · Children or adolescents

The illustrative network meta-regression estimated an SMD for caries increment for fluoride in varnish versus fluoride in rinse across randomization year; the review did not state whether the difference was significant and certainty was not graded.

1 finding from 1 review

Fluoride varnish vs placebo

Caries increment, surface index D(M)FS · Children or adolescents

In the illustrative network meta-regression the SMD for caries increment showed a treatment-by-year interaction and differed between fluoride in varnish and placebo at randomization years 1954 to 1980; certainty was not graded.

1 finding from 1 review

Dementia (any type or severity) vs Older people without dementia

Retained roots (mean number) · Older people (aged 60 years or older) with dementia

Retained roots were more common in older people with dementia (0.2 to 10) than without (0.0 to 1.2); no meta-analysis was performed (ungraded).

1 finding from 1 review

Dementia (any type or severity) vs Older people without dementia

Caries experience (mean DMFT) · Older people (aged 60 years or older) with dementia

The DMFT index was similar between groups, with only 1 of 5 comparative studies finding a significant difference; no meta-analysis was performed (ungraded).

1 finding from 1 review

Dementia (any type or severity) vs Older people without dementia

Denture use (prevalence) · Older people (aged 60 years or older) with dementia

Denture use was similar in older people with and without dementia, though one study reported lower denture use with more severe dementia; no meta-analysis was performed (ungraded).

1 finding from 1 review

Dementia (any type or severity) vs Older people without dementia

Dental caries: prevalence of root caries · Older people (aged 60 years or older) with dementia

Root caries was higher in older people with dementia (0.6 to 4.9) than without (0.3 to 1.7), described as significantly more common but not pooled (ungraded).

1 finding from 1 review

Dementia (any type or severity) vs Older people without dementia

Edentulousness (prevalence) · Older people (aged 60 years or older) with dementia

Edentulousness was similar in older people with and without dementia, with wide overlapping ranges across studies; no meta-analysis was performed (ungraded).

1 finding from 1 review

Dementia (any type or severity) vs Older people without dementia

Orofacial pain (prevalence) · Older people (aged 60 years or older) with dementia

Orofacial pain prevalence was similar in older people with dementia (7.4 to 21.7%) and without dementia (6.7 to 18.5%), based on few studies; no meta-analysis was performed (ungraded).

1 finding from 1 review

Dementia (any type or severity) vs Older people without dementia

Coronal caries (mean number) · Older people (aged 60 years or older) with dementia

Coronal caries was higher in older people with dementia (0.1 to 2.9) than without (0.0 to 1.0), described as significantly more common but not pooled (ungraded).

1 finding from 1 review

Dementia (any type or severity) vs Older people without dementia

Number of teeth · Older people (aged 60 years or older) with dementia

The number of teeth present was comparable between older people with and without dementia; no meta-analysis was performed (ungraded).

1 finding from 1 review

Job-related or family-related stress and pessimistic attitude to life vs Lower stress and no pessimistic attitude

Periodontal disease and serum IL-1β IL-6 and cortisol · Patients with aggressive or chronic periodontitis at a university periodontology department

No correlation was reported between immunological markers cortisol and registered stress values; untreated aggressive periodontitis was accompanied by pessimistic attitude and elevated serum IL-6.

1 finding from 1 review

Selective or stepwise carious tissue removal vs Non-selective or complete carious tissue removal

Proportion of dentists selecting selective or stepwise removal · Dentists surveyed about deep carious lesions in permanent teeth

In Oen 2007, 18% of surveyed dentists selected selective or stepwise removal.

12 findings from 1 review
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