Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,556 questions · 2,794 findings · 119 reviews · All outcomes

No studies found 489 · 17.5%GRADE not reported 1,719 · 61.5%Very low 399 · 14.3%Low 128 · 4.6%Moderate 58 · 2.1%High 1 · 0%

Effervescent tablets vs no treatment

Total anaerobes (colony forming units, log-transformed) · Maxillary complete denture (CD) wearers

Effervescent tablets led to lower total anaerobes (colony forming units, log-transformed) compared with no treatment; GRADE not reported.

1 finding from 1 review

Prophylactic valaciclovir (lower dose) vs Prophylactic valaciclovir (higher dose)

Adverse effects · Patients being treated for cancer (acute leukaemia; chemotherapy or stem-cell transplantation)
1 finding from 1 review

Brushing vs Effervescent tablets

Total anaerobes (colony forming units, log-transformed) · Maxillary complete denture (CD) wearers

Brushing led to higher total anaerobes (colony forming units, log-transformed) compared with effervescent tablets; GRADE not reported.

1 finding from 1 review

Inlay/interposed bone graft (iliac or Bio-Oss block) + longer implants (vertical augmentation) vs Short implants (8 to 11 mm) without augmentation

Implant failure · Patients with atrophic (resorbed) mandibles needing implants

Inlay/interposed bone graft (iliac or Bio-Oss block) + longer… showed no clear difference in implant failure compared with short implants (8 to 11 mm) without augmentation; GRADE not reported.

1 finding from 1 review

Vertical distraction osteogenesis vs Autogenous onlay bone graft (mandibular ramus)

Vertical bone gain · Patients with vertically deficient posterior/anterior mandibular ridges needing implants

Vertical distraction osteogenesis showed no clear difference in vertical bone gain compared with autogenous onlay bone graft (mandibular ramus); GRADE not reported.

1 finding from 1 review

Prophylactic aciclovir (oral or intravenous) vs Prophylactic valaciclovir (oral)

Cost of oral care · Patients being treated for cancer (predominantly haematological malignancies)
1 finding from 1 review

Any denture cleansing method (mechanical or chemical) vs Another method, sham/placebo, or no treatment

Outcome not reported · Wearers of removable partial dentures (RPD), over the age of 18

The review found no eligible studies for this question.

1 finding from 1 review
  • Interventions for cleaning dentures in adults 2009 · Cochrane All outcomes
    No included study assessed removable partial denture (RPD) wearers; all six included trials assessed complete denture wearers (Discussion; Implications for research: 'No included study assessed removable partial…
    0 studies
    No studies found

Vertical distraction osteogenesis vs Autogenous onlay bone graft (mandibular ramus)

Complication at augmentation + donor site · Patients with vertically deficient posterior/anterior mandibular ridges needing implants

Vertical distraction osteogenesis showed no clear difference in complication at augmented + donor site compared with autogenous onlay bone graft (mandibular ramus); GRADE not reported.

1 finding from 1 review

Aciclovir (oral or intravenous) for treatment vs placebo

Adverse effects · Patients being treated for cancer with established oral HSV infection (bone marrow transplant recipients / immunocompromised)
1 finding from 1 review

Inlay autogenous bone graft (iliac crest) vs Inlay bone substitute (Bio-Oss block)

Prosthesis failure · Patients with atrophic posterior mandibles (5 to 7 mm above the mandibular canal) needing implants

Inlay autogenous bone graft (iliac crest) showed no clear difference in prosthesis failure compared with inlay bone substitute (Bio-Oss block); GRADE not reported.

1 finding from 1 review

1-stage (non-submerged) implant placement vs 2-stage (submerged) implant placement

Complications (biological and biomechanical) · People with dental implants

1-stage (non-submerged) implant placement showed no clear difference in complications (biological and biomechanical) compared with 2-stage (submerged) implant placement; GRADE not reported.

1 finding from 1 review

Effervescent tablets vs Association of brushing and effervescent tablets

Fusobacteria (colony forming units, log-transformed) · Maxillary complete denture (CD) wearers

Effervescent tablets showed no clear difference in fusobacteria (colony forming units, log-transformed) compared with association of brushing and effervescent tablets; GRADE not reported.

1 finding from 1 review

Vertical GBR with autogenous bone (retromolar) vs Vertical GBR with bone substitute (Regenaform)

Vertical bone gain · Patients with vertically deficient posterior/anterior mandibular ridges needing implants

Vertical GBR with autogenous bone (retromolar) led to higher vertical bone gain compared with vertical GBR with bone substitute (Regenaform); GRADE not reported.

1 finding from 1 review

Aciclovir (oral or intravenous) for treatment vs placebo

Cost of oral care · Patients being treated for cancer with established oral HSV infection (bone marrow transplant recipients / immunocompromised)

The review found no eligible studies for this question.

1 finding from 1 review

Autogenous bone block from the chin vs Bovine-derived xenograft (Bio-Oss) plus resorbable barrier

Prosthesis/implant failure (1 year) · Patients with horizontally resorbed maxillary sites needing single implants

Autogenous bone block from the chin showed no clear difference in prosthesis/implant failure (1 year) compared with 100% Bio-Oss + resorbable barrier; GRADE not reported.

1 finding from 1 review

Buccal onlay iliac grafts fixed with titanium screws vs Buccal onlay iliac grafts fixed with resorbable screws (split-mouth)

Implant/prosthesis failure and complications · Patients with resorbed maxillae (incl. atrophic sinuses) needing implants
1 finding from 1 review

Ultrasonic treatment or microwave disinfection device vs Another method, sham/placebo, or no treatment

Outcome not reported · Adults (over 18) wearing complete dentures (CD) or removable partial dentures (RPD)

The review found no eligible studies for this question.

1 finding from 1 review
  • Interventions for cleaning dentures in adults 2009 · Cochrane All outcomes
    The effectiveness of ultrasonic or microwave devices as an intervention for routine use was not studied according to a randomised controlled trial design (Implications for research).
    0 studies
    No studies found

Vertical distraction osteogenesis vs Vertical GBR with non-resorbable barriers + particulate autogenous bone

Complication at augmentation + donor site · Patients with vertically deficient posterior/anterior mandibular ridges needing implants

Vertical distraction osteogenesis showed no clear difference in complication at augmentation + donor site compared with vertical GBR with non-resorbable barriers + particulate autogenous…; GRADE not reported.

1 finding from 1 review