Question · asked by 1 review
Prophylactic valaciclovir (lower dose) vs Prophylactic valaciclovir (higher dose): Adverse effects
- Population
- Patients being treated for cancer (acute leukaemia; chemotherapy or stem-cell transplantation)
- Intervention
- Prophylactic valaciclovir (lower dose)
- Comparison
- Prophylactic valaciclovir (higher dose)
- Outcome
- Adverse effects
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Prophylactic valaciclovir (lower dose) vs Prophylactic valaciclovir (higher dose) Adverse effects · Patients being treated for cancer (acute leukaemia; chemotherapy or stem-cell transplantation) Interventions for the prevention and treatment of herpes simplex virus in patients being treated for cancer (2009) · Cochrane All outcomes | One study reported adverse effects (Warkentin 2002). Twenty patients allocated to receive high dose valaciclovir reported adverse effects (42%); for the low dose group this number was 27 (52%). Adverse effects were… | 1 study · 100 participants | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Interventions for the prevention and treatment of herpes simplex virus in patients being treated for cancer 2009 · Cochrane All outcomes | 2008-11 | Not listed | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.