Live birth · people having preimplantation genetic testing for monogenic/single gene defects
It is very uncertain whether day 5 changes live birth compared with day 3 embryo biopsy (very low certainty).
1 finding from 1 review
Miscarriage · people having preimplantation genetic testing for monogenic/single gene defects
It is very uncertain whether day 5 changes miscarriage compared with day 3 embryo biopsy (very low certainty).
1 finding from 1 review
Stillbirth · people having preimplantation genetic testing for monogenic/single gene defects
1 finding from 1 review
Acute kidney injury · adults undergoing cardiac surgery with cardiopulmonary bypass
It is very uncertain whether high changes acute kidney injury compared with low blood pressure target (very low certainty).
1 finding from 1 review
Cognitive deterioration · adults undergoing cardiac surgery with cardiopulmonary bypass
High showed no clear difference in cognitive deterioration compared with low blood pressure target (low certainty).
1 finding from 1 review
All‐cause mortality · adults undergoing cardiac surgery with cardiopulmonary bypass
It is very uncertain whether high changes all‐cause mortality compared with low blood pressure target (very low certainty).
1 finding from 1 review
Quality of life · adults undergoing cardiac surgery with cardiopulmonary bypass
It is very uncertain whether high changes quality of life compared with low blood pressure target (very low certainty).
1 finding from 1 review
Acute ischaemic stroke · adults undergoing cardiac surgery with cardiopulmonary bypass
It is very uncertain whether high changes acute ischaemic stroke compared with low blood pressure target (very low certainty).
1 finding from 1 review
Length of hospital stay · adults undergoing cardiac surgery with cardiopulmonary bypass
1 finding from 1 review
Perioperative transfusion of blood products · adults undergoing cardiac surgery with cardiopulmonary bypass
1 finding from 1 review
Future caries · Children without a previous history of caries
Veillonella spp. predicted future caries among children without a caries history, but no quantitative effect estimate was reported.
1 finding from 1 review
Among children without a previous history of caries, Veillonella spp., but not S. mutans or other acid-producing species, predicted future caries.
1 study · NA (subgroup without prior caries history; n not reported) participants
GRADE not reported
Streptococcus mutans colonization reduction (narrative; no CFU data reported) · Animal caries models (mice, rats, hamsters) challenged/colonized with Streptococcus mutans; one transgenic-plant antigen-expression system
Anticaries vaccines produced a sustained reduction in Streptococcus mutans colonization on teeth in animal models (ungraded narrative synthesis; no pooled estimate).
1 finding from 1 review
no estimate extracted
Studies not reported
GRADE not reported
Relative abundance of S. mutans in saliva · Individuals assessed for dental caries, predominantly children with early childhood caries (ECC) or severe ECC (age about 1 to 4 years)
A few small studies report Streptococcus mutans relative abundance in caries versus caries-free children without pooling; the evidence is ungraded and not meta-analyzed.
1 finding from 1 review
Restoration failure · Permanent posterior teeth (molars/premolars) receiving direct restoration
There was no statistically significant difference in failure risk between composite resin and amalgam restorations in permanent posterior teeth (pooled RR 0.96, 95% CI 0.68 to 1.34; 13 studies; not GRADE-rated, with very high heterogeneity, I2 = 97%).
1 finding from 1 review
Salivary / secretory IgA (SIgA) antibody response (immunogenicity) · Animal caries models (mice, rats, hamsters) challenged/colonized with Streptococcus mutans; one transgenic-plant antigen-expression system
Anticaries vaccines, particularly via mucosal (intranasal) routes, elicited increased salivary/secretory IgA responses in the animal studies (ungraded narrative synthesis; no pooled estimate).
1 finding from 1 review
no estimate extracted
Studies not reported
GRADE not reported
Dental caries and cariogenic bacteria (Streptococcus mutans, Lactobacilli) · Adult e-cigarette (ENDS) users (general oral health; predominantly natural dentition)
E-cigarette use is associated with more cariogenic bacteria and increased dental caries risk compared with non-smokers (narrative synthesis; ungraded).
1 finding from 1 review
Narrative synthesis: e-cigarette use linked to increased cariogenic bacteria (S. mutans, Lactobacilli) and worsening dental caries, with flavored e-liquids noted as a caries risk factor (Zieba, Camoni, Yang…
3 studies
GRADE not reported
Self-reported gingivitis · Adult e-cigarette (ENDS) users (general oral health; predominantly natural dentition)
E-cigarette use is associated with self-reported gingivitis compared with non-smokers (single included review; ungraded).
1 finding from 1 review
Oral microbiota composition (dysbiosis; increased periodontal/opportunistic pathogens) · Adult e-cigarette (ENDS) users (general oral health; predominantly natural dentition)
E-cigarette use is associated with oral microbiota dysbiosis and increased pathogenic bacteria compared with non-smokers (narrative synthesis; ungraded).
1 finding from 1 review
Serum IgG antibody response (immunogenicity) · Animal caries models (mice, rats, hamsters) challenged/colonized with Streptococcus mutans; one transgenic-plant antigen-expression system
Anticaries vaccines elicited increased serum IgG antibody responses across the animal studies (ungraded narrative synthesis; no pooled estimate).
1 finding from 1 review
no estimate extracted
Studies not reported
GRADE not reported
Caries experience (mean DMFT) · 12-year-old children across European countries (national/regional epidemiological surveys, 2011-2022)
Across European countries the overall pooled mean DMFT in 12-year-olds was 2.10 (95% CI 1.63 to 2.57), with very high between-country heterogeneity (I2=100%); not GRADE-rated.
1 finding from 1 review