What do systematic reviews say?

Oral protein calorie supplements vs no intervention, placebo or additional nutritional advice compared to placebo

• Oral protein calorie supplementation for children with chronic disease 2015 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 53 participants
  High

Intervention not reported

• Extent of lymph node dissection for adenocarcinoma of the stomach 2015 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 862 participants
  Moderate

Intervention not reported

The intervention leads to higher postoperative mortality (within 30 days from surgery) (high certainty).

• Extent of lymph node dissection for adenocarcinoma of the stomach 2015 · Cochrane Headline outcomes only
  RR 2.02 [1.34, 3.04]
  5 studies · 1653 participants
  High

Tetanus diphtheria toxoid immunisation of women of reproductive age vs cholera toxoid

Tetanus diphtheria toxoid immunisation of women of reproductive age may leads to lower neonatal mortality in the first 28 days of life compared with cholera toxoid (low certainty).

• Vaccines for women for preventing neonatal tetanus 2015 · Cochrane Headline outcomes only
  RR 0.68 [0.56, 0.82]
  1 study · 8641 participants
  Low

Tetanus diphtheria toxoid immunisation of women of reproductive age vs cholera toxoid

Tetanus diphtheria toxoid immunisation of women of reproductive age may leads to lower neonatal mortality between day 4‐14 of life compared with cholera toxoid (low certainty).

• Vaccines for women for preventing neonatal tetanus 2015 · Cochrane Headline outcomes only
  RR 0.38 [0.27, 0.55]
  1 study · 8641 participants
  Low

Caffeine reduction vs control

• Lifestyle interventions for the treatment of urinary incontinence in adults 2015 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 74 participants
  Very low

Intervention not reported

It is very uncertain whether the intervention changes days on ventilator (selenium) (very low certainty).

• Selenium supplementation for critically ill adults 2015 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 191 participants
  Very low

Transmyocardial laser revascularization vs medical treatment

Transmyocardial laser revascularization showed no clear difference in early postoperative mortality Deaths in the 30 days after surgery compared with medical treatment (high certainty).

• Transmyocardial laser revascularization versus medical therapy for refractory angina 2015 · Cochrane Headline outcomes only
  OR 1.19 [0.63, 2.24]
  6 studies · 967 participants
  High

Any supplements containing iron and folic acid vs same supplements without iron nor folic acid (no iron nor folic acid or placebo)

(Infant outcomes) Any supplements containing iron and folic acid showed no clear difference in neonatal death (within 28 days after delivery) (ALL) compared with same supplements without iron nor folic acid (no iron nor folic acid… (low certainty).

• Daily oral iron supplementation during pregnancy 2015 · Cochrane Headline outcomes only
  RR 0.81 [0.51, 1.3]
  3 studies · 1793 participants
  Low

Any supplements containing iron and folic acid vs same supplements without iron nor folic acid (no iron nor folic acid or placebo)

• Daily oral iron supplementation during pregnancy 2015 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 131 participants
  Low

Any supplements containing iron vs same supplements without iron or no treatment/placebo (no iron or placebo)

(Infant outcomes) Any supplements containing iron showed no clear difference in neonatal death (within 28 days after delivery) (ALL) compared with same supplements without iron or no treatment/placebo (no iron or… (low certainty).

• Daily oral iron supplementation during pregnancy 2015 · Cochrane Headline outcomes only
  RR 0.91 [0.71, 1.18]
  4 studies · 16603 participants
  Low

Any supplements containing iron vs same supplements without iron or no treatment/placebo (no iron or placebo)

It is very uncertain whether (Maternal outcomes) Any supplements containing iron changes maternal death (death while pregnant or within 42 days of… compared with same supplements without iron or no treatment/placebo (no iron or… (very low certainty).

• Daily oral iron supplementation during pregnancy 2015 · Cochrane Headline outcomes only
  RR 0.33 [0.01, 8.19]
  2 studies · 12560 participants
  Very low

Intervention not reported

It is very uncertain whether the intervention changes clinical cure rates at day 8 ± 1 (very low certainty).

• Antibiotics for acute laryngitis in adults 2015 · Cochrane Headline outcomes only
  RR 1.07 [0.88, 1.31]
  1 study · 93 participants
  Very low

Intervention not reported

It is very uncertain whether the intervention changes clinical cure rates at day 8 ± 1 (very low certainty).

• Antibiotics for acute laryngitis in adults 2015 · Cochrane Headline outcomes only
  RR 1.09 [0.9, 1.32]
  1 study · 97 participants
  Very low

Honey vs standard dressing

• Honey as a topical treatment for wounds 2015 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 213 participants
  Very low

Honey vs silver sulfadiazine

• Honey as a topical treatment for wounds 2015 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 332 participants
  Very low

Honey vs standard dressing

• Honey as a topical treatment for wounds 2015 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 992 participants
  High

Intervention not reported

It is very uncertain whether the intervention changes all‐cause mortality up to 30 days (very low certainty).

• Granulocyte transfusions for preventing infections in people with neutropenia or neutrophil dysfunction 2015 · Cochrane Headline outcomes only
  RR 0.92 [0.63, 1.36]
  7 studies · 437 participants
  Very low

Intervention not reported

It is very uncertain whether the intervention changes mortality due to infection up to 30 days (very low certainty).

• Granulocyte transfusions for preventing infections in people with neutropenia or neutrophil dysfunction 2015 · Cochrane Headline outcomes only
  RR 0.69 [0.33, 1.44]
  6 studies · 286 participants
  Very low

Intervention not reported

The intervention showed no clear difference in days hospitalized after delivery (Any psychosocial intervention vs.… (moderate certainty).

• Psychosocial interventions for pregnant women in outpatient illicit drug treatment programs compared to other… 2015 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 103 participants
  Moderate