Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,454 questions · 3,562 findings · 816 reviews · Headline outcomes only

No studies found 538 · 15.1%GRADE not reported 239 · 6.7%Very low 933 · 26.2%Low 1,041 · 29.2%Moderate 612 · 17.2%High 199 · 5.6%

Metoclopramide vs promethazine

Severity, reduction or cessation in nausea/vomiting 2. Number of episodes of emesis 3. Days of hospital admission 4. Pregnancy complications 5. Adverse fetal/neonatal outcomes · Pregnant women with hyperemesis gravidarum

The review found no eligible studies for this question.

1 finding from 1 review

Ondansetron vs promethazine

Length of hospital stay · Pregnant women with hyperemesis gravidarum

It is very uncertain whether ondansetron changes days of hospital admission compared with promethazine (very low certainty).

1 finding from 1 review

Corticosteroids vs promethazine

Intervention side effects: drowsiness 48hrs and 3‐10 days · Pregnant women with hyperemesis gravidarum

Corticosteroids showed no clear difference in intervention side effects: drowsiness 48hrs and 3‐10 days compared with promethazine (low certainty).

1 finding from 1 review

Sulodexide + local treatment vs local treatment

Ulcers completely healed · people with venous leg ulcers

It is very uncertain whether sulodexide + local treatment changes proportion of ulcers completely healed at 30 days compared with local treatment (very low certainty).

3 findings from 1 review

Nitroglycerin vs no treatment

All‐cause mortality in 30 days post operation · patients (15 years of age and older) undergoing non‐cardiac surgery under any type of anaesthesia

It is very uncertain whether nitroglycerin changes all‐cause mortality in 30 days post operation compared with no treatment (very low certainty).

1 finding from 1 review

Nitroglycerin vs placebo

All‐cause mortality in 30 days post operation · patients (15 years of age and older) undergoing non‐cardiac surgery under any type of anaesthesia

It is very uncertain whether nitroglycerin changes all‐cause mortality in 30 days post operation compared with placebo (very low certainty).

1 finding from 1 review