Cochrane · systematic review · CD010694
Sulodexide for treating venous leg ulcers
Wu, B, Lu, J, Yang, M, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
WoundsAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
10
current version
GRADE rated
5
No studies
5
Included studies
NR
No studies 5 · 50%Ungraded 0 · 0%Very low 2 · 20%Low 3 · 30%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Sulodexide + local treatment compared to local treatment for treating venous leg ulcers
Population: patients with venous leg ulcers
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Proportion of ulcers completely healed (overall) Sulodexide + local treatment vs local treatment | RR 1.66 [1.3, 2.12] | 3 studies · 438 participants | Low Downgraded: risk of bias |
Proportion of ulcers completely healed at 30 days Sulodexide + local treatment vs local treatment | RR 1.91 [1, 3.66] | 1 study · 114 participants | Very low Downgraded: risk of bias, imprecision |
Proportion of ulcers completely healed at 60 days Sulodexide + local treatment vs local treatment | RR 1.65 [1.2, 2.28] | 2 studies · 324 participants | Low Downgraded: risk of bias |
Proportion of ulcers completely healed at 90 days Sulodexide + local treatment vs local treatment | RR 1.6 [1.17, 2.2] | 1 study · 230 participants | Low Downgraded: risk of bias, imprecision |
Time to complete ulcer healing Sulodexide + local treatment vs local treatment | no estimate extracted | NR | No studies |
Change in absolute ulcer size Sulodexide + local treatment vs local treatment | no estimate extracted | NR | No studies |
Ulcer recurrence Sulodexide + local treatment vs local treatment | no estimate extracted | NR | No studies |
Adverse effects Sulodexide + local treatment vs local treatment | RR 1.44 [0.48, 4.34] | 2 studies · 344 participants | Very low Downgraded: risk of bias, imprecision |
Health‐related quality of life Sulodexide + local treatment vs local treatment | no estimate extracted | NR | No studies |
Direct costs Sulodexide + local treatment vs local treatment | no estimate extracted | NR | No studies |