Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

480 questions · 484 findings · 52 reviews · Musculoskeletal

No studies found 114 · 23.6%GRADE not reported 24 · 5%Very low 33 · 6.8%Low 145 · 30%Moderate 116 · 24%High 52 · 10.7%

Methotrexate vs placebo

SAEs · psoriatic arthritis

Methotrexate showed no clear difference in serious adverse events (SAEs) assessed by number of events compared with placebo (low certainty).

1 finding from 1 review

Methotrexate vs placebo

Withdrawals due to adverse events · psoriatic arthritis

Methotrexate showed no clear difference in withdrawals due to adverse events (WAEs) assessed by number of events compared with placebo (low certainty).

1 finding from 1 review

Corticosteroids (dexamethasone) vs placebo

Number of participants with normal physical joint function ‐ normal function at 12 months of · septic arthritis in children taking antibiotics

Corticosteroids (dexamethasone) may leads to higher number of participants with normal physical joint function ‐ normal… compared with placebo (low certainty).

1 finding from 1 review

Corticosteroids (dexamethasone) vs placebo

Number of days of antibiotic treatment ‐ number of days of intravenous antibiotic treatment · septic arthritis in children taking antibiotics

Corticosteroids (dexamethasone) showed no clear difference in number of days of antibiotic treatment ‐ number of days of… compared with placebo (low certainty).

1 finding from 1 review

Bisphosphonates vs placebo

Number of participants with change in bone pain (disappearance of pain)¹assessed on VAS · Paget's disease of bone

Bisphosphonates probably leads to higher number of participants with change in bone pain (disappearance of… compared with placebo (moderate certainty).

1 finding from 1 review

Bisphosphonates vs placebo

Number of participants who experienced radiologically‐confirmed fractures · Paget's disease of bone

It is very uncertain whether bisphosphonates changes number of participants who experienced radiologically‐confirmed… compared with placebo (very low certainty).

1 finding from 1 review