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Evidence found and GRADE certainty

282 questions · 313 findings · 24 reviews

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No studies found 89 · 28.4%GRADE not reported 15 · 4.8%Very low 102 · 32.6%Low 75 · 24%Moderate 27 · 8.6%High 5 · 1.6%

Metformin vs insulin

Hypertensive disorders of pregnancy: pre‐eclampsia · women with type 2 diabetes

It is very uncertain whether maternal outcomes: oral anti‐diabetic agent (metformin) changes hypertensive disorders of pregnancy: pre‐eclampsia compared with insulin (very low certainty).

1 finding from 1 review

Metformin vs insulin

Hypertensive disorders of pregnancy (pregnancy‐induced hypertension) · women with type 2 diabetes

Maternal outcomes: oral anti‐diabetic agent (metformin) may leads to lower hypertensive disorders of pregnancy: pregnancy‐induced hypertension compared with insulin (low certainty).

1 finding from 1 review

Pharmacological interventions vs pharmacological intervention

Adverse events ‐ Metformin plus liraglutide vs metformin Nausea Diarrhoea Headache · obese women with subfertility

It is very uncertain whether pharmacological intervention changes adverse events ‐ Metformin plus liraglutide vs metformin Nausea… compared with pharmacological intervention (very low certainty).

1 finding from 1 review

Pharmacological interventions vs pharmacological intervention

Clinical pregnancyMetformin plus liraglutide vs metformin Met + CC + L‐carnitine vs Met + CC + placebo · obese women with subfertility

It is very uncertain whether pharmacological intervention changes clinical pregnancyMetformin plus liraglutide vs metformin Met + CC +… compared with pharmacological intervention (very low certainty).

1 finding from 1 review

Pharmacological interventions vs pharmacological intervention

Weight ‐ BMI changeMetformin plus liraglutide vs metformin Met + CC + L‐carnitine vs Met + CC + placebo Weight changeDexfenfluramine vs placebo Weight ‐ body fatMetformin plus liraglutide vs metformin · obese women with subfertility
1 finding from 1 review

Summary of findings: pioglitazone monotherapy vs another pharmacological glucose‐lowering monotherapy

Metformin · people at increased risk for developing type 2 diabetes
2 findings from 1 review

Summary of findings: pioglitazone monotherapy vs another pharmacological glucose‐lowering monotherapy

Metformin Diagnostic criteria: 2 studies applied the WHO 1999 criteria for 'prediabetes' (FPG > 6.1 mmol/L and < 7.0 mmol/L and/or a 2‐h glucose < 11.1 mmol/L after a 75 g OGTT; Chen 2007a; Zeng 2013) · people at increased risk for developing type 2 diabetes

Summary of findings: pioglitazone monotherapy showed no clear difference in metformin Diagnostic criteria: 2 studies applied the WHO 1999… compared with another pharmacological glucose‐lowering monotherapy (low certainty).

1 finding from 1 review