Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,815 questions · 6,211 findings · 638 reviews · Headline outcomes only

No studies found 1,052 · 16.9%GRADE not reported 441 · 7.1%Very low 1,700 · 27.4%Low 1,651 · 26.6%Moderate 1,070 · 17.2%High 297 · 4.8%

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Intervention not reported

Overall survival ‐ trials of metastatic breast cancer participants unselected for TNBC · women with metastatic breast cancer unselected for triple‐negative breast cancer (TNBC)

The intervention showed no clear difference in overall survival ‐ trials of metastatic breast cancer participants… (high certainty).

1 finding from 1 review

Intervention not reported

Progression‐free survival/time to progression (randomised participants) ‐ trials of metastatic breast cancer participants unselected for TNBC · women with metastatic breast cancer unselected for triple‐negative breast cancer (TNBC)

The intervention showed no clear difference in progression‐free survival/time to progression (randomised… (moderate certainty).

1 finding from 1 review

Intervention not reported

Objective tumour response rate (assessable participants) ‐ trials of metastatic breast cancer participants unselected for TNBC · women with metastatic breast cancer unselected for triple‐negative breast cancer (TNBC)

The intervention may leads to higher objective tumour response rate (assessable participants) ‐ trials of… (low certainty).

1 finding from 1 review

Exposure to any ovary‐stimulating drugs for subfertility vs untreated subfertile women and endometrial cancer risk

Endometrial cancer · Women treated with ovary‐stimulating drugs for subfertility

It is very uncertain whether exposure to any ovary‐stimulating drugs for subfertility changes endometrial cancer compared with untreated subfertile women and endometrial cancer risk (very low certainty).

1 finding from 1 review

Exposure to any ovary‐stimulating drugs for subfertility vs general population and endometrial cancer risk

Endometrial cancer · Women treated with ovary‐stimulating drugs for subfertility

It is very uncertain whether exposure to any ovary‐stimulating drugs for subfertility changes endometrial cancer compared with general population and endometrial cancer risk (very low certainty).

1 finding from 1 review

Exposure to clomiphene citrate for subfertility vs untreated subfertile women and endometrial cancer risk

Endometrial cancer · Women treated with ovary‐stimulating drugs for subfertility

It is very uncertain whether exposure to clomiphene citrate for subfertility changes endometrial cancer compared with untreated subfertile women and endometrial cancer risk (very low certainty).

1 finding from 1 review

Exposure to clomiphene citrate for subfertility vs general population and endometrial cancer risk

Endometrial cancer · Women treated with ovary‐stimulating drugs for subfertility

It is very uncertain whether exposure to clomiphene citrate for subfertility changes endometrial cancer compared with general population and endometrial cancer risk (very low certainty).

1 finding from 1 review

Exposure to gonadotropins for subfertility vs untreated subfertile women and endometrial cancer risk

Endometrial cancer · Women treated with ovary‐stimulating drugs for subfertility

It is very uncertain whether exposure to gonadotropins for subfertility changes endometrial cancer compared with untreated subfertile women and endometrial cancer risk (very low certainty).

1 finding from 1 review

Exposure to gonadotropins for subfertility vs general population and endometrial cancer risk

Endometrial cancer · Women treated with ovary‐stimulating drugs for subfertility

It is very uncertain whether exposure to gonadotropins for subfertility changes endometrial cancer compared with general population and endometrial cancer risk (very low certainty).

1 finding from 1 review

Exposure to clomiphene citrate and gonadotropins for subfertility vs untreated subfertile women and endometrial cancer risk

Endometrial cancer · Women treated with ovary‐stimulating drugs for subfertility

It is very uncertain whether exposure to clomiphene citrate and gonadotropins for subfertility changes endometrial cancer compared with untreated subfertile women and endometrial cancer risk (very low certainty).

1 finding from 1 review

Exposure to clomiphene citrate and gonadotropins for subfertility vs general population and endometrial cancer risk

Endometrial cancer · Women treated with ovary‐stimulating drugs for subfertility

It is very uncertain whether exposure to clomiphene citrate and gonadotropins for subfertility changes endometrial cancer compared with general population and endometrial cancer risk (very low certainty).

1 finding from 1 review

GnRH analogues vs untreated subfertile women and endometrial cancer risk

Endometrial cancer · Women treated with ovary‐stimulating drugs for subfertility

It is very uncertain whether exposure to GnRH analogues for subfertility changes endometrial cancer compared with untreated subfertile women and endometrial cancer risk (very low certainty).

1 finding from 1 review

Dexamethasone vs betamethasone – child outcomes

Developmental delay –motor (mild, moderate or severe) · women at risk of preterm birth

Dexamethasone showed no clear difference in developmental delay –motor (mild, moderate or severe) compared with betamethasone – child outcomes (moderate certainty).

1 finding from 1 review

Dexamethasone vs betamethasone – child outcomes

Intellectual impairment: developmental delay – cognitive or language (mild, moderate or severe) · women at risk of preterm birth

Dexamethasone showed no clear difference in intellectual impairment: developmental delay – cognitive or language… compared with betamethasone – child outcomes (moderate certainty).

1 finding from 1 review