Findings

What do systematic reviews say?

315 questions · 322 findings · 87 reviews · Neonatal

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No studies found 47 · 14.6%GRADE not reported 18 · 5.6%Very low 78 · 24.2%Low 105 · 32.6%Moderate 50 · 15.5%High 24 · 7.5%

Volume‐targeted vs pressure‐limited ventilation: additional findings

Death or BPD (28 days) · neonates up to 44 weeks' postmenstrual age

Volume‐targeted showed no clear difference in death or BPD (28 days) compared with pressure‐limited ventilation: additional findings (low certainty).

1 finding from 1 review

Volume‐targeted versus pressure‐limited ventilation in neonates 2017 · Cochrane Headline outcomes only
RR 0.87 [0.64, 1.18]
3 studies · 149 participants
Low

Sildenafil plus iNO vs placebo plus iNO

Length of hospital stay · pulmonary hypertension in neonates

1 finding from 1 review

Sildenafil for pulmonary hypertension in neonates 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 24 participants
Low

Antibiotics vs no antibiotics

Incidence of confirmed sepsis in first 28 days · symptomatic neonates born through meconium‐stained amniotic fluid

1 finding from 1 review

Antibiotics for neonates born through meconium‐stained amniotic fluid 2017 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 445 participants
Low

Antibiotics vs no antibiotics

Duration of oxygen therapy (hours) · symptomatic neonates born through meconium‐stained amniotic fluid

1 finding from 1 review

Antibiotics for neonates born through meconium‐stained amniotic fluid 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 405 participants
Low

Antibiotics vs no antibiotics

Length of hospital stay · symptomatic neonates born through meconium‐stained amniotic fluid

1 finding from 1 review

Antibiotics for neonates born through meconium‐stained amniotic fluid 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 146 participants
Moderate

Antibiotics vs no antibiotics

Incidence of confirmed sepsis in first 28 days · asymptomatic neonates born through meconium‐stained amniotic fluid

1 finding from 1 review

Antibiotics for neonates born through meconium‐stained amniotic fluid 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 250 participants
Low

Antibiotics vs no antibiotics

Duration of oxygen therapy (hours) · asymptomatic neonates born through meconium‐stained amniotic fluid

1 finding from 1 review

Antibiotics for neonates born through meconium‐stained amniotic fluid 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 250 participants
Low

Intravenous fluid supplementation vs no fluid supplementation

Frequency of breastfeeding per day · newborn infants with unconjugated hyperbilirubinaemia undergoing phototherapy

1 finding from 1 review

Fluid supplementation for neonatal unconjugated hyperbilirubinaemia 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 60 participants
Moderate

Vitamin A vs no supplementation

Chronic lung disease · promoting growth and development in very low birth weight infants receiving human milk

Supplemental vitamin A showed no clear difference in chronic lung disease (oxygen use at 28 days in survivors) compared with no supplementation (moderate certainty).

1 finding from 1 review

Vitamin A supplementation to prevent mortality and short‐ and long‐term morbidity in very low birth weight infants 2016 · Cochrane Headline outcomes only
RR 0.93 [0.86, 1.01]
7 studies · 1070 participants
Moderate

Vitamin A vs no supplementation

Death or chronic lung disease · promoting growth and development in very low birth weight infants receiving human milk

Supplemental vitamin A probably leads to lower death or chronic lung disease (oxygen use at 28 days) compared with no supplementation (moderate certainty).

1 finding from 1 review

Vitamin A supplementation to prevent mortality and short‐ and long‐term morbidity in very low birth weight infants 2016 · Cochrane Headline outcomes only
RR 0.93 [0.88, 0.99]
6 studies · 1165 participants
Moderate

Non‐nutritive sucking (NNS) vs no NNS

Gavage to full oral feeding (days) · preterm infants

1 finding from 1 review

Non‐nutritive sucking for increasing physiologic stability and nutrition in preterm infants 2016 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 87 participants
Low

Non‐nutritive sucking (NNS) vs no NNS

Start oral feeding to full oral feeding (days) · preterm infants

1 finding from 1 review

Non‐nutritive sucking for increasing physiologic stability and nutrition in preterm infants 2016 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 100 participants
Very low

Non‐nutritive sucking (NNS) vs no NNS

Days from birth to full oral breastfeeding · preterm infants

1 finding from 1 review

Non‐nutritive sucking for increasing physiologic stability and nutrition in preterm infants 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 303 participants
Low

Non‐nutritive sucking (NNS) vs no NNS

Length of hospital stay · preterm infants

1 finding from 1 review

Non‐nutritive sucking for increasing physiologic stability and nutrition in preterm infants 2016 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 501 participants
Low

Non‐nutritive sucking (NNS) vs no NNS

Daily weight gain · preterm infants

1 finding from 1 review

Non‐nutritive sucking for increasing physiologic stability and nutrition in preterm infants 2016 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 103 participants
Low

Non‐nutritive sucking (NNS) vs no NNS

Postconceptual age at full oral feeds (days) · preterm infants

1 finding from 1 review

Non‐nutritive sucking for increasing physiologic stability and nutrition in preterm infants 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 28 participants
Very low

Intervention not reported

Weight gain in first 7 days of study (g/day) · Newborn infants unable to fully breastfeed

1 finding from 1 review

Cup feeding versus other forms of supplemental enteral feeding for newborn infants unable to fully breastfeed 2016 · Cochrane Headline outcomes only
no estimate extracted
522 participants
Low

Intervention not reported

Length of stay (days) · Newborn infants unable to fully breastfeed

1 finding from 1 review

Cup feeding versus other forms of supplemental enteral feeding for newborn infants unable to fully breastfeed 2016 · Cochrane Headline outcomes only
no estimate extracted
823 participants
Low

Responsive vs scheduled feeding

Rate of weight gain (g/kg/day) · preterm infants

1 finding from 1 review

Responsive versus scheduled feeding for preterm infants 2016 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 305 participants
Low

Cycled light (CL) vs irregular dimmed light or near darkness (ND)

Length of stay (days) (CL from 32 weeks' PMA) · preterm or low birth weight infants undergoing hospital care

1 finding from 1 review

Cycled light in the intensive care unit for preterm and low birth weight infants 2016 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 77 participants
Low