Dental maturation (tooth calcification) · Children and adolescents with juvenile idiopathic arthritis (JIA)
Evidence on dental maturation was divergent across two studies (one found more advanced maturation in JIA, one found no difference); no clear conclusion (ungraded).
1 finding from 1 review
Arrest or reversal of noncavitated occlusal carious lesions · Children and adults with noncavitated carious lesions on occlusal surfaces (primary and permanent teeth)
0.2% NaF mouthrinse + supervised toothbrushing was probably less effective than Sealant + 5% NaF varnish for arrest or reversal of occlusal carious lesions (RR 0.58, 95% CI 0.43 to 0.79; moderate certainty).
1 finding from 1 review
Pathological mobility · Children with carious vital pulp exposure in primary incisors
Pathological mobility was rare (one tooth in one of four trials) and was not pooled.
1 finding from 1 review
Arrest or reversal of noncavitated carious lesions on any coronal surface · Children and adults with noncavitated carious lesions on any coronal surface (primary and permanent teeth)
10% CPP-ACP paste may not differ from no treatment for arrest or reversal of any-coronal carious lesions (RR 1.03, 95% CI 0.9 to 1.18; low certainty).
1 finding from 1 review
Plaque · Medically healthy individuals (adults and children, 6-60 years)
0.12% chlorhexidine rinse reduced plaque relative to baseline; not GRADE-rated.
1 finding from 1 review
Pathological root resorption · Children with carious vital pulp exposure in primary incisors
No statistically significant difference in pathological root resorption between pulpotomy and pulpectomy (RR 1.5, 95% CI 0.56 to 4.04; ungraded).
1 finding from 1 review
RR 1.5 [0.56, 4.04]
2 studies
GRADE not reported
Average enamel surface roughness · Extracted human teeth with early/artificial enamel lesions (in vitro)
In vitro, CPP-ACP markedly reduced enamel surface roughness versus control (SMD -8.21, 95% CI -10.37 to -6.04; ungraded).
1 finding from 1 review
Plaque · Medically healthy individuals (adults and children, 6-60 years)
Salvadora persica rinse reduced plaque relative to its own baseline; not GRADE-rated.
1 finding from 1 review
Arrest or reversal of noncavitated occlusal carious lesions · Children and adults with noncavitated carious lesions on occlusal surfaces (primary and permanent teeth)
1.23% APF gel may not differ from 5% NaF varnish for arrest or reversal of occlusal carious lesions (RR 1.08, 95% CI 0.83 to 1.4; low certainty).
2 findings from 1 review
Streptococcus mutans count · Medically healthy individuals (adults and children, 6-60 years)
Placebo rinse did not significantly change Streptococcus mutans counts relative to baseline; not GRADE-rated.
1 finding from 1 review
Physiological stress indicators (heart rate, oxygen saturation) · Children (ages 6-12) receiving pit-and-fissure sealants
Heart rate and oxygen saturation did not differ significantly between laser-plus-acid and acid-etching (ungraded, single study).
1 finding from 1 review
Arrest or reversal of noncavitated occlusal carious lesions · Children and adults with noncavitated carious lesions on occlusal surfaces (primary and permanent teeth)
0.2% NaF mouthrinse + supervised toothbrushing may not differ from 5% NaF varnish for arrest or reversal of occlusal carious lesions (RR 0.99, 95% CI 0.84 to 1.15; low certainty).
1 finding from 1 review
Arrest or reversal of noncavitated and cavitated root carious lesions · Adults (including institutionalized/older adults) with noncavitated and cavitated carious lesions on root surfaces (permanent teeth)
5% NaF varnish may not differ from no treatment for arrest or reversal of root carious lesions (RR 2.96, 95% CI 0.27 to 32.26; very low certainty).
1 finding from 1 review
Intervention not reported
Dental caries prevalence · Children (<12 years) and adolescents (12-18 years) with type 1 diabetes
The pooled prevalence of dental caries among children and adolescents with type 1 diabetes was 67% (95% CI 0.56 to 0.77), with high heterogeneity (I2=83%); certainty not graded.
1 finding from 1 review
Unmet dental treatment need · Children aged 1-18 years
Narrative reports from 6 studies suggested greater unmet dental treatment need in children with learning disabilities (5 of 6 studies), but no quantitative data were available (certainty not graded).
1 finding from 1 review
Arrest or reversal of noncavitated and cavitated root carious lesions · Adults (including institutionalized/older adults) with noncavitated and cavitated carious lesions on root surfaces (permanent teeth)
1% chlorhexidine + 1% thymol varnish may not differ from 5% NaF varnish for arrest or reversal of root carious lesions (RR 0.57, 95% CI 0.04 to 8.69; very low certainty).
1 finding from 1 review
DMFT/DMFS index (dental caries experience) · Children with dental caries
Oral-health promotion programs were associated with markedly lower odds of DMFT/S in children (OR 0.19, 95% CI 0.10 to 0.39; ungraded, very high heterogeneity I2=98.5%).
1 finding from 1 review
OR 0.19 [0.10, 0.39]
8 studies
GRADE not reported
Arrest or reversal of noncavitated approximal carious lesions · Children and adults with noncavitated carious lesions on approximal surfaces (primary and permanent teeth)
5% NaF varnish may not differ from no treatment for arrest or reversal of approximal carious lesions (RR 2.29, 95% CI 0.74 to 7.1; very low certainty).
1 finding from 1 review
Overall success (composite of clinical and radiographic success) · Immature (young) permanent teeth with open apex and vital pulp exposed to dental caries or trauma, in children aged 6-14 years
A single RCT found higher pulpotomy success with MTA than abscess remedy (100% vs 80%; statistically significant, P<0.05; not pooled; ungraded).
1 finding from 1 review
Single RCT (Eppa 2018, 3-arm; 20 MTA and 20 AR teeth): MTA 100% (20/20) vs abscess remedy 80% (16/20) clinical and radiographic success; the 4 abscess-remedy failures occurred at 3 months; difference statistically…
1 study · 40 participants
GRADE not reported
Arrest or reversal of noncavitated approximal carious lesions · Children and adults with noncavitated carious lesions on approximal surfaces (primary and permanent teeth)
Resin infiltration may not differ from Sealant for arrest or reversal of approximal carious lesions (RR 0.88, 95% CI 0.4 to 1.91; very low certainty).
1 finding from 1 review