Findings

What do systematic reviews say?

3,535 questions · 3,601 findings · 252 reviews · Pregnancy and Childbirth

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No studies found 726 · 20.2%GRADE not reported 421 · 11.7%Very low 828 · 23%Low 993 · 27.6%Moderate 486 · 13.5%High 147 · 4.1%

Metformin vs insulin

Childhood/adulthood adiposity · women with type 2 diabetes

1 finding from 1 review

Oral anti‐diabetic agents for women with established diabetes/impaired glucose tolerance or previous gestational… 2017 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Metformin vs insulin

Childhood/adulthood diabetes · women with type 2 diabetes

1 finding from 1 review

Oral anti‐diabetic agents for women with established diabetes/impaired glucose tolerance or previous gestational… 2017 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Metformin vs insulin

Hypertensive disorders of pregnancy (pregnancy‐induced hypertension) · women with type 2 diabetes

Maternal outcomes: oral anti‐diabetic agent (metformin) may leads to lower hypertensive disorders of pregnancy: pregnancy‐induced hypertension compared with insulin (low certainty).

1 finding from 1 review

Oral anti‐diabetic agents for women with established diabetes/impaired glucose tolerance or previous gestational… 2017 · Cochrane Headline outcomes only
RR 0.58 [0.37, 0.91]
1 study · 206 participants
Low

Metformin vs insulin

Caesarean section · women with type 2 diabetes

Maternal outcomes: oral anti‐diabetic agent (metformin) may leads to lower caesarean section compared with insulin (low certainty).

1 finding from 1 review

Oral anti‐diabetic agents for women with established diabetes/impaired glucose tolerance or previous gestational… 2017 · Cochrane Headline outcomes only
RR 0.73 [0.61, 0.88]
3 studies · 241 participants
Low

Metformin vs insulin

Induction of labour · women with type 2 diabetes

It is very uncertain whether maternal outcomes: oral anti‐diabetic agent (metformin) changes induction of labour compared with insulin (very low certainty).

1 finding from 1 review

Oral anti‐diabetic agents for women with established diabetes/impaired glucose tolerance or previous gestational… 2017 · Cochrane Headline outcomes only
RR 1.42 [0.62, 3.28]
2 studies · 35 participants
Very low

Metformin vs insulin

Perineal trauma · women with type 2 diabetes

1 finding from 1 review

Oral anti‐diabetic agents for women with established diabetes/impaired glucose tolerance or previous gestational… 2017 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Metformin vs insulin

Postnatal depression · women with type 2 diabetes

1 finding from 1 review

Oral anti‐diabetic agents for women with established diabetes/impaired glucose tolerance or previous gestational… 2017 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Metformin vs insulin

Postnatal weight retention · women with type 2 diabetes

1 finding from 1 review

Oral anti‐diabetic agents for women with established diabetes/impaired glucose tolerance or previous gestational… 2017 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Metformin vs insulin

Large‐for‐gestational age · women with type 2 diabetes

It is very uncertain whether infant outcomes: oral anti‐diabetic agent (metformin) changes large‐for‐gestational age compared with insulin (very low certainty).

1 finding from 1 review

Oral anti‐diabetic agents for women with established diabetes/impaired glucose tolerance or previous gestational… 2017 · Cochrane Headline outcomes only
RR 1.12 [0.73, 1.72]
1 study · 206 participants
Very low

Metformin vs insulin

Perinatal mortality · women with type 2 diabetes

1 finding from 1 review

Oral anti‐diabetic agents for women with established diabetes/impaired glucose tolerance or previous gestational… 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 220 participants
Very low

Preconception care vs usual care

Pregnancy · adolescent girls with type 1 or 2 diabetes

1 finding from 1 review

Preconception care for diabetic women for improving maternal and infant health 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 109 participants
Very low

Preconception care vs usual care

Mortality or morbidity composite · adolescent girls with type 1 or 2 diabetes

1 finding from 1 review

Preconception care for diabetic women for improving maternal and infant health 2017 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Preconception care vs usual care

Babies born with congenital malformations · adolescent girls with type 1 or 2 diabetes

1 finding from 1 review

Preconception care for diabetic women for improving maternal and infant health 2017 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Preconception care vs usual care

Adiposity · adolescent girls with type 1 or 2 diabetes

1 finding from 1 review

Preconception care for diabetic women for improving maternal and infant health 2017 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Preconception care vs usual care

Type 1 or 2 diabetes · adolescent girls with type 1 or 2 diabetes

1 finding from 1 review

Preconception care for diabetic women for improving maternal and infant health 2017 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Preconception care vs usual care

Neurosensory disability · adolescent girls with type 1 or 2 diabetes

1 finding from 1 review

Preconception care for diabetic women for improving maternal and infant health 2017 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Preconception care vs usual care

Hypertensive disorders of pregnancy · adolescent girls with type 1 or 2 diabetes

1 finding from 1 review

Preconception care for diabetic women for improving maternal and infant health 2017 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Preconception care vs usual care

Caesarean section · adolescent girls with type 1 or 2 diabetes

1 finding from 1 review

Preconception care for diabetic women for improving maternal and infant health 2017 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Preconception care vs usual care

Perineal trauma · adolescent girls with type 1 or 2 diabetes

1 finding from 1 review

Preconception care for diabetic women for improving maternal and infant health 2017 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Preconception care vs usual care

Gestational weight gain · adolescent girls with type 1 or 2 diabetes

1 finding from 1 review

Preconception care for diabetic women for improving maternal and infant health 2017 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported