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What do systematic reviews say?

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Evidence found and GRADE certainty

3,696 questions · 3,815 findings · 855 reviews

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No studies found 573 · 15%GRADE not reported 374 · 9.8%Very low 993 · 26%Low 1,062 · 27.8%Moderate 614 · 16.1%High 199 · 5.2%

Intervention not reported

Change in total protein (g/day): at 12 months · adults and children with cystic fibrosis
1 finding from 1 review

Intervention not reported

Change in total fat (g/day): at 12 months · adults and children with cystic fibrosis
1 finding from 1 review

Intervention not reported

Length of initial hospital stay (days) · people with stroke

The intervention probably leads to higher length of initial hospital stay (days) (moderate certainty).

1 finding from 1 review

Inhaled NO vs control

Mortality before hospital discharge · respiratory failure in preterm infants

Inhaled NO showed no clear difference in death before discharge ‐ Studies with entry before 3 days based on… compared with control (high certainty).

2 findings from 1 review

Inhaled NO vs control

Neurodevelopmental disability · respiratory failure in preterm infants

Inhaled NO showed no clear difference in neurodevelopmental disability ‐ Studies with entry after 3 days… compared with control (moderate certainty).

2 findings from 1 review

Inhaled NO vs control

Death or bronchopulmonary dysplasia · respiratory failure in preterm infants

Inhaled NO showed no clear difference in death or bronchopulmonary dysplasia at 36 weeks ‐ Studies with entry… compared with control (high certainty).

1 finding from 1 review

Inhaled NO vs control

Death or bronchopulmonary dysplasia at 36 weeks PMA · respiratory failure in preterm infants

Inhaled NO showed no clear difference in death or bronchopulmonary dysplasia at 36 weeks ‐ Studies with entry… compared with control (high certainty).

1 finding from 1 review

Inhaled NO vs control

Intraventricular haemorrhage, Papile grade 3/4 · respiratory failure in preterm infants

Inhaled NO showed no clear difference in intraventricular haemorrhage (grade 3 or 4) ‐ Studies with entry… compared with control (high certainty).

1 finding from 1 review

Low molecular weight heparin vs UFH

Incidence of recurrent VTE1 after initial treatment (up to 15 days) · patients with venous thromboembolism.

LMWH probably leads to lower incidence of recurrent VTE1 after initial treatment (up to 15 days) compared with UFH (moderate certainty).

1 finding from 1 review

Buprenorphine vs alpha2‐adrenergic agonists

Mean days in treatment (with varying scheduled duration) · Adults or adolescents with opioid dependence

Buprenorphine probably leads to higher mean days in treatment (with varying scheduled duration) compared with alpha2‐adrenergic agonists (moderate certainty).

1 finding from 1 review

Intervention not reported

Poor neurological outcome by 28 days' postnatal age · neonates requiring intubation and ventilation

The intervention showed no clear difference in poor neurological outcome by 28 days' postnatal age (moderate certainty).

1 finding from 1 review

Inhaled steroids vs systemic corticosteroids

Death or BPD (28 days) · preterm infants with respiratory distress for initial respiratory support

Inhaled steroids showed no clear difference in death or BPD at 28 days compared with systemic corticosteroids (low certainty).

1 finding from 1 review