Change in dystonia from baseline Measured by: BADS (eight body regions assessed for dystonia on a five‐point scale (0 = none to 4 = severe), minimum score 0 to maximum score 32; higher score = greater severity of dystonia) · children with dystonic cerebral palsy
1 finding from 1 review
no estimate extracted
16 participants
Low
Adverse effectsb (mood disturbance, irritability, behavioural change, constipation) Measured by: counts of number and type · children with dystonic cerebral palsy
Summary of findings: Trihexyphenidyl may leads to higher adverse effectsb (mood disturbance, irritability, behavioural… compared with placebo (low certainty).
1 finding from 1 review
RR 2.54 [1.38, 4.67]
16 participants
Low
Participation in activities of daily living:individual goal setting Measured by: GAS (up to 5 functional goals scored on a 5‐point scale (−2 = much less than expected to +2 = much more than expected); higher score = better than expected outcome) · children with dystonic cerebral palsy
1 finding from 1 review
no estimate extracted
16 participants
Low
Participation in activities of daily living:satisfaction with individual goals Measured by: satisfaction subscale of the COPM (satisfaction with performance in up to 5 problem areas scored on a 10‐point scale (1 = not satisfied at all to 10 = extr... · children with dystonic cerebral palsy
1 finding from 1 review
no estimate extracted
16 participants
Low
Participation in activities of daily living:performance of individual goals Measured by: performance subscale of the COPM (up to five problem areas scored on a 10‐point scale (1 = not able to do to 10 = able to do extremely well; higher score = be... · children with dystonic cerebral palsy
1 finding from 1 review
no estimate extracted
16 participants
Low
Quality of life · children with dystonic cerebral palsy
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Aggression · Disruptive behaviours in children and youths
2 findings from 1 review
Conduct · Disruptive behaviours in children and youths
1 finding from 1 review
Weight gain · Disruptive behaviours in children and youths
2 findings from 1 review
Anaemia · preschool and school‐age children
Point‐of‐use fortification of foods with micronutrients powders (MNP) probably leads to lower anaemia (defined as haemoglobin < 110 g/L for children aged 24‐59… compared with no intervention or placebo (moderate certainty).
1 finding from 1 review
Haemoglobin (g/dL) · preschool and school‐age children
1 finding from 1 review
Iron deficiency (using ferritin concentrations) · preschool and school‐age children
Point‐of‐use fortification of foods with micronutrients powders (MNP) probably leads to lower iron deficiency (defined by using ferritin concentrations less than… compared with no intervention or placebo (moderate certainty).
1 finding from 1 review
Ferritin (µg/L) · preschool and school‐age children
1 finding from 1 review
All‐cause mortality (number of deaths during trial) · preschool and school‐age children
1 finding from 1 review
Diarrhoea · preschool and school‐age children
Point‐of‐use fortification of foods with micronutrients powders (MNP) showed no clear difference in diarrhoea (≥ 3 liquid stools per day) compared with no intervention or placebo (low certainty).
1 finding from 1 review
Any adverse effects (e.g. hypervitaminosis A, as defined by the trialists) · preschool and school‐age children
Point‐of‐use fortification of foods with micronutrients powders (MNP) showed no clear difference in adverse effects (any, as defined by trialists) compared with no intervention or placebo (moderate certainty).
1 finding from 1 review
Pain frequency or change in pain frequency · Children with recurrent abdominal pain
1 finding from 1 review
Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · Children with recurrent abdominal pain
1 finding from 1 review
Relief of pain · Children with recurrent abdominal pain
Probiotics probably leads to higher improvement in pain: 0 to 3 months' postintervention Different… compared with placebo (moderate certainty).
2 findings from 1 review
Improvement in pain: 0 to 3 months' postintervention Subgroup (irritable bowel syndrome) Different measures were used to assess improvement in pain, as above. · Children with recurrent abdominal pain
Probiotics probably leads to higher improvement in pain: 0 to 3 months' postintervention Subgroup… compared with placebo (moderate certainty).
1 finding from 1 review