Cochrane · systematic review · CD012430
Trihexyphenidyl for dystonia in cerebral palsy
Harvey, AR, Baker, LB, Reddihough, DS, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
Developmental, Psychosocial and Learning ProblemsAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
5
No studies
1
Included studies
NR
No studies 1 · 16.7%Ungraded 0 · 0%Very low 0 · 0%Low 5 · 83.3%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Summary of findings: Trihexyphenidyl compared with placebo for dystonia in cerebral palsy
Population: children with dystonic cerebral palsy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Change in dystonia from baseline Measured by: BADS (eight body regions assessed for dystonia on a five‐point scale (0 = none to 4 = severe), minimum score 0 to maximum score 32; higher score = greater severity of dystonia) Summary of findings: Trihexyphenidyl vs placebo | no estimate extracted | 16 participants | Low Downgraded: imprecision |
Adverse effectsb (mood disturbance, irritability, behavioural change, constipation) Measured by: counts of number and type Summary of findings: Trihexyphenidyl vs placebo | RR 2.54 [1.38, 4.67] | 16 participants | Low Downgraded: imprecision |
Participation in activities of daily living:individual goal setting Measured by: GAS (up to 5 functional goals scored on a 5‐point scale (−2 = much less than expected to +2 = much more than expected); higher score = better than expected outcome) Summary of findings: Trihexyphenidyl vs placebo | no estimate extracted | 16 participants | Low Downgraded: imprecision |
Participation in activities of daily living:satisfaction with individual goals Measured by: satisfaction subscale of the COPM (satisfaction with performance in up to 5 problem areas scored on a 10‐point scale (1 = not satisfied at all to 10 = extr... Summary of findings: Trihexyphenidyl vs placebo | no estimate extracted | 16 participants | Low Downgraded: imprecision |
Participation in activities of daily living:performance of individual goals Measured by: performance subscale of the COPM (up to five problem areas scored on a 10‐point scale (1 = not able to do to 10 = able to do extremely well; higher score = be... Summary of findings: Trihexyphenidyl vs placebo | no estimate extracted | 16 participants | Low Downgraded: imprecision |
Quality of life Summary of findings: Trihexyphenidyl vs placebo | no estimate extracted | NR | No studies |