Findings

What do systematic reviews say?

279 questions · 289 findings · 28 reviews · Headline outcomes only

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No studies found 81 · 28%GRADE not reported 9 · 3.1%Very low 90 · 31.1%Low 67 · 23.2%Moderate 24 · 8.3%High 18 · 6.2%

NSAIDs vs paracetamol

Return to function on day 7 or later (numbers returning to full function or returning to training) · people with acute soft tissue injury, such as ankle sprain

It is very uncertain whether NSAID changes return to function on day 7 or latere compared with paracetamol (very low certainty).

1 finding from 1 review

Oral non‐steroidal anti‐inflammatory drugs versus other oral analgesic agents for acute soft tissue injury 2020 · Cochrane Headline outcomes only
RR 0.99 [0.9, 1.09]
3 studies · 386 participants
Very low

NSAIDs vs paracetamol

Gastrointestinal adverse events · people with acute soft tissue injury, such as ankle sprain

NSAID showed no clear difference in gastrointestinal adverse events compared with paracetamol (low certainty).

1 finding from 1 review

Oral non‐steroidal anti‐inflammatory drugs versus other oral analgesic agents for acute soft tissue injury 2020 · Cochrane Headline outcomes only
RR 1.34 [0.97, 1.86]
10 studies · 1504 participants
Low

NSAIDs vs paracetamol

Neurological adverse effects · people with acute soft tissue injury, such as ankle sprain

NSAID showed no clear difference in neurological adverse events compared with paracetamol (low certainty).

1 finding from 1 review

Oral non‐steroidal anti‐inflammatory drugs versus other oral analgesic agents for acute soft tissue injury 2020 · Cochrane Headline outcomes only
RR 0.85 [0.62, 1.17]
9 studies · 1679 participants
Low

NSAIDs vs paracetamol

Early re‐injury (with 3 months) · people with acute soft tissue injury, such as ankle sprain

The review found no eligible studies for this question.

1 finding from 1 review

Oral non‐steroidal anti‐inflammatory drugs versus other oral analgesic agents for acute soft tissue injury 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

SDAC vs no intervention

Incidence of mortality · first aid in patients with acute oral poisoning (paracetamol or not specified)

The review found no eligible studies for this question.

1 finding from 1 review

First aid interventions by laypeople for acute oral poisoning 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

SDAC vs no intervention

Incidence of adverse events · first aid in patients with acute oral poisoning (paracetamol or not specified)

1 finding from 1 review

First aid interventions by laypeople for acute oral poisoning 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 476 participants
Very low

SDAC vs no intervention

Incidence and severity of symptoms of poisoning: incidence of clinical deterioration during stay in the hospital · first aid in patients with acute oral poisoning (paracetamol or not specified)

1 finding from 1 review

First aid interventions by laypeople for acute oral poisoning 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 451 participants
Very low

SDAC vs no intervention

Duration of toxic symptoms · first aid in patients with acute oral poisoning (paracetamol or not specified)

The review found no eligible studies for this question.

1 finding from 1 review

First aid interventions by laypeople for acute oral poisoning 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

SDAC vs no intervention

Drug absorption · first aid in patients with acute oral poisoning (paracetamol or not specified)

The review found no eligible studies for this question.

1 finding from 1 review

First aid interventions by laypeople for acute oral poisoning 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

SDAC vs no intervention

Hospitalization · first aid in patients with acute oral poisoning (paracetamol or not specified)

The review found no eligible studies for this question.

1 finding from 1 review

First aid interventions by laypeople for acute oral poisoning 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

SDAC vs no intervention

Incidence of admissions to the ICU · first aid in patients with acute oral poisoning (paracetamol or not specified)

1 finding from 1 review

First aid interventions by laypeople for acute oral poisoning 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 451 participants
Very low

NSAIDs vs paracetamol

Relief of pain · women with primary dysmenorrhoea

NSAIDs may leads to higher pain relief dichotomous data compared with paracetamol (low certainty).

1 finding from 1 review

Nonsteroidal anti‐inflammatory drugs for dysmenorrhoea 2015 · Cochrane Headline outcomes only
OR 1.89 [1.05, 3.43]
Studies not reported
Low

NSAIDs vs placebo

to 72 hours (48 hours)

NSAIDs may leads to lower to 72 hours (48 hours) compared with placebo (low certainty).

1 finding from 1 review

Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
RR 0.28 [0.11, 0.7]
1 study · 146 participants
Low

NSAIDs vs placebo

to 7 days

The review found no eligible studies for this question.

1 finding from 1 review

Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

NSAIDs vs placebo

Adverse events

It is very uncertain whether NSAIDs changes adverse events compared with placebo (very low certainty).

1 finding from 1 review

Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
RR 1.76 [0.44, 7.1]
1 study · 146 participants
Very low

NSAIDs vs placebo

Mean time to resolution of pain

The review found no eligible studies for this question.

1 finding from 1 review

Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

NSAIDs vs placebo

Mean pain score at various time points

The review found no eligible studies for this question.

1 finding from 1 review

Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

NSAIDs vs placebo

Reconsultations

The review found no eligible studies for this question.

1 finding from 1 review

Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

NSAIDs vs placebo

Delayed antibiotic prescriptions

The review found no eligible studies for this question.

1 finding from 1 review

Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

NSAIDs vs placebo

hours

The review found no eligible studies for this question.

1 finding from 1 review

Paracetamol (acetaminophen) or non‐steroidal anti‐inflammatory drugs, alone or combined, for pain relief in acute… 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found