Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,410 questions · 8,901 findings · 1,091 reviews

No studies found 1,687 · 19%GRADE not reported 1,469 · 16.5%Very low 1,969 · 22.1%Low 2,060 · 23.1%Moderate 1,302 · 14.6%High 414 · 4.7%

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HFNC vs continuous positive airway pressure (CPAP)

Treatment failure within 72 hours of trial entry · preterm infants requiring primary respiratory support

Nasal high flow probably leads to higher treatment failure within 72 hours of trial entry compared with continuous positive airway pressure (moderate certainty).

1 finding from 1 review

HFNC vs continuous positive airway pressure (CPAP)

Mechanical ventilation within 72 hours of trial entry · preterm infants requiring primary respiratory support

Nasal high flow showed no clear difference in mechanical ventilation within 72 hours of trial entry compared with continuous positive airway pressure (moderate certainty).

1 finding from 1 review

HFNC vs nasal intermittent positive pressure ventilation

Death (before hospital discharge) or BPD (supplemental oxygen/respiratory support at 36 weeks' postmenstrual age if born < 32 weeks' gestation, or 28 days if born ≥ 32 weeks' gestation) · preterm infants requiring primary respiratory support

It is very uncertain whether nasal high flow changes death (before hospital discharge) or BPD (supplemental… compared with nasal intermittent positive pressure ventilation (very low certainty).

1 finding from 1 review

Partial pulpotomy with one-unit longer follow-up vs Partial pulpotomy with one-unit shorter follow-up

Overall success (composite of clinical and radiographic success) · Adults aged 18 years or older with mature permanent teeth and carious pulp exposure

In the high-risk-study-excluded sensitivity meta-regression, longer follow-up was associated with lower success.

1 finding from 1 review

Bonded Minne appliance (slow maxillary expansion) vs Banded Minne appliance (slow maxillary expansion)

Stability of crossbite correction (relapse of canine expansion) · Children and adults with a posterior crossbite, without a Class III skeletal relationship, cleft lip or palate (or both), or other…
1 finding from 1 review

Bonded Minne appliance (slow maxillary expansion) vs Banded Minne appliance (slow maxillary expansion)

Stability of crossbite correction (relapse of molar expansion) · Children and adults with a posterior crossbite, without a Class III skeletal relationship, cleft lip or palate (or both), or other…
1 finding from 1 review

Hyperbaric oxygen therapy (HBO) following extractions vs penicillin G

Incidence of ORN · Adults with head and neck cancer undergoing curative or adjuvant radiotherapy (at risk of osteoradionecrosis of the jaws)

It is very uncertain whether hyperbaric oxygen therapy (HBO) following extractions changes incidence of ORN compared with perioperative antibiotic prophylaxis (penicillin G) following… (very low certainty).

1 finding from 1 review

Hyperbaric oxygen therapy (HBO) following extractions vs penicillin G

Adverse effects · Adults with head and neck cancer undergoing curative or adjuvant radiotherapy (at risk of osteoradionecrosis of the jaws)
1 finding from 1 review

Standard pressure ulcer education and monthly mail or telephone follow‐up, vs standard pressure ulcer education and quarterly mail or telephone follow‐up,

Proportion of participants developing a new ulcer · s

It is very uncertain whether standard pressure ulcer education and monthly mail or telephone… changes proportion of participants developing a new ulcer (24 months) compared with standard pressure ulcer education and quarterly mail or telephone… (very low certainty).

1 finding from 1 review