Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,696 questions · 3,815 findings · 855 reviews

No studies found 573 · 15%GRADE not reported 374 · 9.8%Very low 993 · 26%Low 1,062 · 27.8%Moderate 614 · 16.1%High 199 · 5.2%

Prophylactic platelet transfusion prior to surgery vs no prophylactic platelet transfusion prior to surgery

Number of participants with major bleeding within 7 days of surgery (surgical site bleeding requiring a second intervention or reoperation or surgical site bleeding that causes a haematoma or haemarthrosis of sufficient size to delay mobilisation ... · people with a low platelet count

It is very uncertain whether prophylactic platelet transfusion prior to surgery changes number of participants with major bleeding within 7 days of surgery… compared with no prophylactic platelet transfusion prior to surgery (very low certainty).

1 finding from 1 review

Prophylactic platelet transfusion prior to surgery vs no prophylactic platelet transfusion prior to surgery

Number of participants with minor procedure‐related bleeding within 7 days of surgery · people with a low platelet count

It is very uncertain whether prophylactic platelet transfusion prior to surgery changes the number of participants with minor procedure‐related bleeding… compared with no prophylactic platelet transfusion prior to surgery (very low certainty).

1 finding from 1 review

Keratinocyte growth factor (KGF; palifermin or repifermin), intravenous vs placebo

Number of days in hospital · Adults with cancer receiving treatment

Keratinocyte growth factor (KGF; palifermin or repifermin),… showed no clear difference in number of days in hospital compared with placebo; GRADE not reported.

1 finding from 1 review

Keratinocyte growth factor (KGF; palifermin or repifermin), intravenous vs placebo

Number of days unable to take medicine orally · Adults with cancer receiving treatment

The review found no eligible studies for this question.

1 finding from 1 review

Resorbable (bioresorbable) plates or screws for fixation vs Titanium plates or screws for fixation

Costs (fixation materials, hospital bed days, retreatment) · Adults (>16 years old) undergoing orthognathic surgery

The review found no eligible studies for this question.

1 finding from 1 review

Periodontal treatment (scaling and root planing, alone or with antimicrobials) vs Alternative (less intensive) periodontal treatment, alone or with placebo

Perinatal mortality · Pregnant women considered to have periodontal disease (gingivitis or periodontitis) after dental examination

It is very uncertain whether periodontal treatment (scaling and root planing, alone or with… changes perinatal mortality (including fetal and neonatal deaths up to the… compared with alternative (less intensive) periodontal treatment, alone or with… (very low certainty).

1 finding from 1 review

Open surgical exposure vs Closed surgical exposure

Patient response: moderate or severe pain at 1 day postoperative · People with maxillary palatally displaced (impacted) canines, unilateral or bilateral (children/adolescents; mean ages 14.2 to 17.5 years)

Open surgical exposure showed no clear difference in patient response: moderate or severe pain at 1 day postoperative compared with closed surgical exposure; GRADE not reported.

1 finding from 1 review

Keratinocyte growth factor (KGF; palifermin or repifermin), intravenous vs placebo

Interruptions to cancer treatment (unscheduled radiotherapy breaks of 5 or more days) · Adults with cancer receiving treatment

Keratinocyte growth factor (KGF; palifermin or repifermin),… showed no clear difference in interruptions to cancer treatment (unscheduled radiotherapy breaks… compared with placebo; GRADE not reported.

1 finding from 1 review

Low‐molecular‐weight heparins or heparinoids vs unfractionated heparin

Death from all causes during treatment (range 6 days to 16 days) · acute ischaemic stroke

Low‐molecular‐weight heparins or heparinoids showed no clear difference in death from all causes during treatment (range 6 days to 16 days) compared with unfractionated heparin (low certainty).

1 finding from 1 review

Low‐molecular‐weight heparins or heparinoids vs unfractionated heparin

Deep vein thrombosis · acute ischaemic stroke

Low‐molecular‐weight heparins or heparinoids may leads to lower deep vein thrombosis during treatment period (range 6 days to 16 days) compared with unfractionated heparin (low certainty).

1 finding from 1 review

Low‐molecular‐weight heparins or heparinoids vs unfractionated heparin

Pulmonary embolism · acute ischaemic stroke

Low‐molecular‐weight heparins or heparinoids showed no clear difference in pulmonary embolism during treatment period (range 6 days to 16 days) compared with unfractionated heparin (low certainty).

1 finding from 1 review