Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,971 questions · 9,849 findings · 853 reviews

No studies found 1,150 · 11.7%GRADE not reported 3,387 · 34.4%Very low 1,963 · 19.9%Low 1,809 · 18.4%Moderate 1,207 · 12.3%High 333 · 3.4%

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Calcium hydroxide (CH) vs Biodentine

Overall success (composite of clinical and radiographic success) · Patients with carious pulp exposure in permanent teeth undergoing DPC or pulpotomy

Biodentine appeared to perform better than calcium hydroxide for success, but the evidence was not pooled (2 RCTs; ungraded).

1 finding from 1 review

Polyether impression material vs Polyvinyl siloxane impression material

Pulp necrosis · Vital teeth

The pooled incidence with polyether impression material was 4.02%.

2 findings from 1 review

Herbal mouthwash vs placebo

Gingival inflammation-related index · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)

Herbal mouthwash reduced gingival inflammation-related indices versus placebo, but certainty is very low.

1 finding from 1 review

Calcium hydroxide (CH) vs Mineral trioxide aggregate (MTA)

Overall success (composite of clinical and radiographic success) · Patients with carious pulp exposure in mature permanent teeth

In mature teeth, MTA probably achieves higher clinical and radiographic success than calcium hydroxide (OR 3.34, 95% CI 1.81-6.17; moderate certainty).

1 finding from 1 review

Fluoride varnish vs CPP-ACFP

Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic lesions, active caries…

Fluoride varnish did not differ significantly from CPP-ACFP (SMD 0.18, 95% CI -0.29 to 0.64); certainty of evidence not assessed (no GRADE).

1 finding from 1 review

Mineral trioxide aggregate (MTA) vs Calcium hydroxide (CH)

Overall success (composite of clinical and radiographic success) · Patients with carious pulp exposure in permanent teeth undergoing direct pulp capping

MTA increases clinical and radiographic success versus CH after direct pulp capping (moderate certainty).

1 finding from 1 review

Balloon (Foley or ATAD) vs vaginal prostaglandin E2

Vaginal delivery not achieved within 24 hours · third trimester induction of labour in women with a viable fetus

Balloon (Foley or ATAD) showed no clear difference in vaginal delivery not achieved in 24 hours compared with vaginal prostaglandin E2 (low certainty).

1 finding from 1 review

Balloon (Foley or ATAD) vs low‐dose vaginal misoprostol

Serious neonatal morbidity or perinatal death · third trimester induction of labour in women with a viable fetus

It is very uncertain whether balloon (Foley or ATAD) changes serious neonatal morbidity or perinatal death compared with low‐dose vaginal misoprostol (very low certainty).

1 finding from 1 review

Balloon (Foley or ATAD) vs low‐dose oral misoprostol

Vaginal delivery not achieved within 24 hours · third trimester induction of labour in women with a viable fetus

Balloon (Foley or ATAD) probably leads to higher vaginal delivery not achieved within 24 hours compared with low‐dose oral misoprostol (moderate certainty).

1 finding from 1 review

Balloon (Foley or ATAD) vs low‐dose oral misoprostol

Uterine hyperstimulation with fetal heart rate changes · third trimester induction of labour in women with a viable fetus

Balloon (Foley or ATAD) showed no clear difference in uterine hyperstimulation with FHR changes compared with low‐dose oral misoprostol (low certainty).

1 finding from 1 review

Balloon (Foley or ATAD) vs low‐dose oral misoprostol

Serious neonatal morbidity or perinatal death · third trimester induction of labour in women with a viable fetus

Balloon (Foley or ATAD) showed no clear difference in serious neonatal morbidity or perinatal death compared with low‐dose oral misoprostol (low certainty).

1 finding from 1 review

Balloon (Foley or ATAD) vs vaginal prostaglandin E2

Uterine hyperstimulation with fetal heart rate changes · third trimester induction of labour in women with a viable fetus

Balloon (Foley or ATAD) probably leads to lower uterine hyperstimulation with FHR changes compared with vaginal prostaglandin E2 (moderate certainty).

1 finding from 1 review