Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,543 questions · 2,589 findings · 168 reviews · Schizophrenia

No studies found 601 · 23.2%GRADE not reported 446 · 17.2%Very low 721 · 27.8%Low 505 · 19.5%Moderate 274 · 10.6%High 42 · 1.6%

PERPHENAZINE vs LOW‐POTENCY ANTIPSYCHOTIC DRUGS

Adverse effects ‐ movement disorders ‐ At least one movement disorder · patients with schizophrenia

Comparison 1: PERPHENAZINE showed no clear difference in adverse effects ‐ movement disorders ‐ at least one movement disorder compared with LOW‐POTENCY ANTIPSYCHOTIC DRUGS (low certainty).

1 finding from 1 review

TRIFLUOPERAZINE vs LOW‐POTENCY ANTIPSYCHOTIC DRUGS

Acceptability of treatment ‐ leaving the study early · patients with schizophrenia

Trifluoperazine showed no clear difference in leaving the study early: 1. Acceptability of treatment ‐ leaving… compared with low‐potency antipsychotic drugs (low certainty).

1 finding from 1 review

TRIFLUOPERAZINE vs LOW‐POTENCY ANTIPSYCHOTIC DRUGS

Adverse effects/events: at least 1 adverse effect ‐ as defined by individual studies. · patients with schizophrenia

Trifluoperazine showed no clear difference in adverse events: 1. General ‐ at least one adverse effect compared with low‐potency antipsychotic drugs (moderate certainty).

1 finding from 1 review

TRIFLUOPERAZINE vs LOW‐POTENCY ANTIPSYCHOTIC DRUGS

Adverse effects ‐ movement disorders ‐ At least one movement disorder · patients with schizophrenia

Trifluoperazine showed no clear difference in adverse events: 2.a. Specific ‐ movement disorders ‐ at least one… compared with low‐potency antipsychotic drugs (low certainty).

1 finding from 1 review

Horticultural therapy plus standard care vs usual care

Well‐being and quality of life Personal Wellbeing Index (PWI‐C) . Scale from: 0 to 77 (low = poor) · patients with schizophrenia

It is very uncertain whether horticultural therapy plus standard care changes well‐being and quality of life Personal Wellbeing Index (PWI‐C) .… compared with standard care alone (very low certainty).

1 finding from 1 review

Horticultural therapy plus standard care vs usual care

Satisfaction with treatment: leaving the study early Endpoint data (events) · patients with schizophrenia

It is very uncertain whether horticultural therapy plus standard care changes satisfaction with treatment Leaving the study early compared with standard care alone (very low certainty).

1 finding from 1 review

Horticultural therapy plus standard care vs usual care

Mental state and behaviour DASS21. Scale from: 0 to 84 (high = poor) · patients with schizophrenia

It is very uncertain whether horticultural therapy plus standard care changes mental state and behaviour DASS21. Scale from: 0 to 84 (high = poor) compared with standard care alone (very low certainty).

1 finding from 1 review

BRIEF FAMILY INTERVENTION vs usual care

Hospital admissions · patients with schizophrenia

It is very uncertain whether BRIEF FAMILY INTERVENTION changes service utilisation ‐ hospital admission ‐ medium to long term… compared with STANDARD CARE (very low certainty).

1 finding from 1 review