Findings

What do systematic reviews say?

2,434 questions · 2,594 findings · 269 reviews

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No studies found 543 · 20.9%GRADE not reported 191 · 7.4%Very low 676 · 26.1%Low 732 · 28.2%Moderate 399 · 15.4%High 53 · 2%

Education, self‐monitoring plus education, and decision aids vs usual care

Anxiety · oral anticoagulant therapy in patients with atrial fibrillation

1 finding from 1 review

Educational and behavioural interventions for anticoagulant therapy in patients with atrial fibrillation 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 587 participants
Low

Education, self‐monitoring plus education, and decision aids vs usual care

Depression Measured after 52 weeks HADS depression score, 0‐21 points Low score means fewer symptoms · oral anticoagulant therapy in patients with atrial fibrillation

1 finding from 1 review

Educational and behavioural interventions for anticoagulant therapy in patients with atrial fibrillation 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 587 participants
Low

Education, self‐monitoring plus education, and decision aids vs usual care

Decisional conflict · oral anticoagulant therapy in patients with atrial fibrillation

1 finding from 1 review

Educational and behavioural interventions for anticoagulant therapy in patients with atrial fibrillation 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 721 participants
Low

Uric acid lowering therapies (UAR) vs Placebo, no intervention or usual care (with or without placebo)

Death at 6 months · people with CKD

Uric acid lowering therapies (UAR) showed no clear difference in death at 6 months compared with placebo, no treatment or usual care (low certainty).

1 finding from 1 review

Uric acid lowering therapies for preventing or delaying the progression of chronic kidney disease 2017 · Cochrane Headline outcomes only
RR 1.66 [0.61, 4.48]
2 studies · 498 participants
Low

Uric acid lowering therapies (UAR) vs Placebo, no intervention or usual care (with or without placebo)

Death at 2 years · people with CKD

Uric acid lowering therapies (UAR) showed no clear difference in death at 2 years compared with placebo, no treatment or usual care (low certainty).

1 finding from 1 review

Uric acid lowering therapies for preventing or delaying the progression of chronic kidney disease 2017 · Cochrane Headline outcomes only
RR 0.13 [0.02, 1.06]
2 studies · 220 participants
Low

Uric acid lowering therapies (UAR) vs Placebo, no intervention or usual care (with or without placebo)

Dialysis · people with CKD

Uric acid lowering therapies (UAR) showed no clear difference in dialysis at 2 years compared with placebo, no treatment or usual care (low certainty).

1 finding from 1 review

Uric acid lowering therapies for preventing or delaying the progression of chronic kidney disease 2017 · Cochrane Headline outcomes only
RR 0.4 [0.05, 3]
2 studies · 220 participants
Low

Uric acid lowering therapies (UAR) vs Placebo, no intervention or usual care (with or without placebo)

Creatinine level · people with CKD

1 finding from 1 review

Uric acid lowering therapies for preventing or delaying the progression of chronic kidney disease 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 83 participants
Low

Uric acid lowering therapies (UAR) vs Placebo, no intervention or usual care (with or without placebo)

eGFR or creatinine clearance (mL/min/1.73m²) · people with CKD

1 finding from 1 review

Uric acid lowering therapies for preventing or delaying the progression of chronic kidney disease 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 164 participants
Moderate

Uric acid lowering therapies (UAR) vs Placebo, no intervention or usual care (with or without placebo)

Cardiovascular events · people with CKD

Uric acid lowering therapies (UAR) showed no clear difference in cardiovascular events compared with placebo, no treatment or usual care (low certainty).

1 finding from 1 review

Uric acid lowering therapies for preventing or delaying the progression of chronic kidney disease 2017 · Cochrane Headline outcomes only
RR 0.46 [0.2, 1.04]
1 study · 113 participants
Low

Uric acid lowering therapies (UAR) vs Placebo, no intervention or usual care (with or without placebo)

Serum UA · people with CKD

1 finding from 1 review

Uric acid lowering therapies for preventing or delaying the progression of chronic kidney disease 2017 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 253 participants
High

Individual TF‐CBT vs inactive control (usual care care, attention control, waitlist)

Severity of PTSD symptoms · Adults with co‐morbid PTSD and SMI

1 finding from 1 review

Psychological interventions for post‐traumatic stress disorder (PTSD) in people with severe mental illness 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 13 participants
Low

EMDR vs inactive control (usual care care, attention control, waitlist)

Symptoms of co‐morbid psychosis: 1. Overall mental state · Adults with co‐morbid PTSD and SMI

The review found no eligible studies for this question.

1 finding from 1 review

Psychological interventions for post‐traumatic stress disorder (PTSD) in people with severe mental illness 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

EMDR vs inactive control (usual care care, attention control, waitlist)

Anxiety · Adults with co‐morbid PTSD and SMI

The review found no eligible studies for this question.

1 finding from 1 review

Psychological interventions for post‐traumatic stress disorder (PTSD) in people with severe mental illness 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

EMDR vs inactive control (usual care care, attention control, waitlist)

Depressive symptoms · Adults with co‐morbid PTSD and SMI

The review found no eligible studies for this question.

1 finding from 1 review

Psychological interventions for post‐traumatic stress disorder (PTSD) in people with severe mental illness 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

EMDR vs inactive control (usual care care, attention control, waitlist)

Adverse events ‐ incidents of unspecified severe adverse events ‐ medium term · Adults with co‐morbid PTSD and SMI

1 finding from 1 review

Psychological interventions for post‐traumatic stress disorder (PTSD) in people with severe mental illness 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 102 participants
Low

EMDR vs inactive control (usual care care, attention control, waitlist)

Health economics · Adults with co‐morbid PTSD and SMI

The review found no eligible studies for this question.

1 finding from 1 review

Psychological interventions for post‐traumatic stress disorder (PTSD) in people with severe mental illness 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Individual TF‐CBT vs inactive control (usual care care, attention control, waitlist)

Quality of life: 1. General quality of life · Adults with co‐morbid PTSD and SMI

1 finding from 1 review

Psychological interventions for post‐traumatic stress disorder (PTSD) in people with severe mental illness 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 39 participants
Low

Individual TF‐CBT vs inactive control (usual care care, attention control, waitlist)

Symptoms of co‐morbid psychosis: 1. Overall mental state · Adults with co‐morbid PTSD and SMI

1 finding from 1 review

Psychological interventions for post‐traumatic stress disorder (PTSD) in people with severe mental illness 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 9 participants
Low

Individual TF‐CBT vs inactive control (usual care care, attention control, waitlist)

Anxiety · Adults with co‐morbid PTSD and SMI

1 finding from 1 review

Psychological interventions for post‐traumatic stress disorder (PTSD) in people with severe mental illness 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 9 participants
Very low

Individual TF‐CBT vs inactive control (usual care care, attention control, waitlist)

Depressive symptoms · Adults with co‐morbid PTSD and SMI

1 finding from 1 review

Psychological interventions for post‐traumatic stress disorder (PTSD) in people with severe mental illness 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 48 participants
Very low