Cochrane · systematic review · CD009460
Uric acid lowering therapies for preventing or delaying the progression of chronic kidney disease
Sampson, AL, Singer, RF, Walters, GD · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
Kidney and TransplantAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 5 · 71.4%Moderate 1 · 14.3%High 1 · 14.3%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Uric acid lowering therapies (UAR) versus placebo, no treatment or usual care for preventing or delaying the progression of chronic kidney disease (CKD)
Population: CKD patients
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death at 6 months Uric acid lowering therapies (UAR) vs placebo, no treatment or usual care | RR 1.66 [0.61, 4.48] | 2 studies · 498 participants | Low |
Death at 2 years Uric acid lowering therapies (UAR) vs placebo, no treatment or usual care | RR 0.13 [0.02, 1.06] | 2 studies · 220 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Dialysis at 2 years Uric acid lowering therapies (UAR) vs placebo, no treatment or usual care | RR 0.4 [0.05, 3] | 2 studies · 220 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Serum creatinine at 1 year Uric acid lowering therapies (UAR) vs placebo, no treatment or usual care | no estimate extracted | 2 studies · 83 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
eGFR at 2 years Uric acid lowering therapies (UAR) vs placebo, no treatment or usual care | no estimate extracted | 2 studies · 164 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Cardiovascular events Uric acid lowering therapies (UAR) vs placebo, no treatment or usual care | RR 0.46 [0.2, 1.04] | 1 study · 113 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Uric acid at 1 year Uric acid lowering therapies (UAR) vs placebo, no treatment or usual care | no estimate extracted | 4 studies · 253 participants | High |